61 Result(s)

Article

MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells

Natural killer (NK) cells are important in host to eliminate circulating tumour cells (CTCs) in turn preventing the development of tumour cells into metastasis but the mechanisms are very poorly defined. Here ...

X Liu, Q Chen, J Yan, Y Wang, C Zhu, C Chen, X Zhao, M Xu, Q Sun… in Cell Death & Disease (2013)

Article

TRAF1 is a key mediator for hepatic ischemia/reperfusion injury

Tumor necrosis factor receptor-associated factor 1 (TRAF1), an adapter in signal transduction, is involved in immunity and in apoptotic processes in various cell types. However, little is known about its funct...

X-F Zhang, R Zhang, L Huang, P-X Wang, Y Zhang, D-S Jiang, L-H Zhu… in Cell Death & Disease (2014)

Article

TRPM2 channel deficiency prevents delayed cytosolic Zn²⁺ accumulation and CA1 pyramidal neuronal death after transient global ischemia

Transient ischemia is a leading cause of cognitive dysfunction. Postischemic ROS generation and an increase in the cytosolic Zn²⁺ level ([Zn²⁺]_c) are critical in delayed CA1 pyramidal neuronal death, but the unde...

M Ye, W Yang, J F Ainscough, X-P Hu, X Li, A Sedo, X-H Zhang… in Cell Death & Disease (2014)

Article

Circulating histones are major mediators of systemic inflammation and cellular injury in patients with acute liver failure

Acute liver failure (ALF) is a life-threatening systemic disorder. Here we investigated the impact of circulating histones, recently identified inflammatory mediators, on systemic inflammation and liver injury...

Zongmei Wen, Zhen Lei, Lu Yao, ** Jiang, Tao Gu, Feng Ren… in Cell Death & Disease (2016)

Article

RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis

Dysfunction of nuclear factor-κB (NF-κB) signaling has been causally associated with numerous human malignancies. Although the NF-κB family of genes has been implicated in endometrial carcinogenesis, information ...

Qiu-Lin Ge, San-Hong Liu, Zhi-Hong Ai, Min-Fang Tao, Li Ma… in Cell Death & Disease (2016)

Article

Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis

Transforming growth factor beta (TGFβ) signaling in breast cancer is selectively associated with pulmonary metastasis. However, the underlying mechanisms remain unclear. Here we show that Bcl-3, a member of the I...

** Chen, **nwei Cao, **aohua Sun, Rong Lei, Pengfei Chen… in Cell Death & Disease (2016)

Article

Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity

Severe acute pancreatitis (SAP) still remains a clinical challenge, not only for its high mortality but the uncontrolled inflammatory progression from acute pancreatitis (AP) to SAP. Cell death, including apop...

Yong Liu, **ao-Dong Chen, Jiang Yu, Jun-Lin Chi, Fei-Wu Long… in Cell Death & Disease (2017)

Article

Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis

Distant metastasis is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure while epithelial–mesenchymal transition (EMT) is the critical process of NPC invasion and metastasis. However, tumor-...

Ting Zhang, ** Yin, Zichen Zhang, Banglao Xu, Di Che, Zhiyu Dai… in Cell Death & Disease (2017)

Article

MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion

Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer’s disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery o...

**n Chen, Xue-Mei Jiang, Lin-**g Zhao, Lin-Lin Sun, Mei-Ling Yan… in Cell Death & Disease (2017)

Article

miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma

Gallbladder cancer (GBC) is the most common malignant tumour of the biliary track system. Angiogenesis plays a pivotal role in the development and progression of malignant tumours. miR-143-3p acts as a tumour ...

Yun-Peng **, Yun-** Hu, **ang-Song Wu, Yao-Shi Wu, Yuan-Yuan Ye… in Cell Death & Disease (2018)

Article

Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons

Emerging evidence supports an important role for the ROS-sensitive TRPM2 channel in mediating age-related cognitive impairment in Alzheimer’s disease (AD), particularly neurotoxicity resulting from generation ...

**n Li, Lin-Hua Jiang in Cell Death & Disease (2018)

Article

GRK5 functions as an oncogenic factor in non-small-cell lung cancer

Lung cancer is the leading cause of cancer-related deaths worldwide, and non-small-cell lung cancer (NSCLC) accounts for about 80% of all cases, which is the major subgroup of lung cancer. G protein-coupled re...

Li-** Jiang, Song-Qing Fan, Qiu-**a **ong, Yong-Chun Zhou… in Cell Death & Disease (2018)

Article

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In thi...

Shu-Jie Zhao, Yi-Fei Shen, Qing Li, Yun-Jie He, Yun-Kun Zhang… in Cell Death & Disease (2018)

Article

MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7

Gallbladder carcinoma (GBC), the most common malignant tumour of the bile duct, is highly aggressive and has a poor prognosis. MicroRNA-30a-5p (miR-30a-5p) is an important tumour suppressor that participates i...

Yuan-Yuan Ye, Jia-Wei Mei, Shan-Shan **ang, Huai-Feng Li, Qiang Ma… in Cell Death & Disease (2018)

Article

Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy

The homologous recombination (HR) pathway is a promising target for cancer therapy as it is frequently upregulated in tumors. One such strategy is to target tumors with cancer-specific, hyperactive promoters o...

Yu Chen, Zhen Li, Zhu Xu, Huanyin Tang, Wenxuan Guo, … in Cell Death & Disease (2018)

Article

Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression

The activation of androgen receptor (AR) signaling plays an essential role in both prostate stromal cells and epithelial cells during the development of benign prostatic hyperplasia (BPH). Here we demonstrated...

Chen-Yi Jiang, Bo-Yu Yang, Sheng Zhao, Si-Hui Shao, **ao-Yu Bei… in Cell Death & Disease (2018)

Article

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation

Non-small-cell lung cancer (NSCLC) is the predominant histological type of lung cancer and is characterized by the highest mortality and incidence rates among these types of malignancies. Cardiac glycosides, a...

Run-Ze Li, **ng-**ng Fan, Fu-Gang Duan, Ze-Bo Jiang, Hu-Dan Pan… in Cell Death & Disease (2018)

Article

Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway componen...

Yingshi Zhang, Dandan Li, Qiyu Jiang, Shuang Cao, Huiwei Sun… in Cell Death & Disease (2018)

Article

Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression

Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unc...

Yi-pin Lv, Liu-sheng Peng, Qi-hong Wang, Na Chen, Yong-sheng Teng… in Cell Death & Disease (2018)

Article

PLZF play as an indirect facilitator of thymic retention for the innate-like T-cells to aquire innate-like functions

**n Cao, **ao-xia Ma, Yu-jia Xue, Yan Zeng, **an-yu Zhang, Ying Lu… in Cell Death & Disease (2018)