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Open AccessHuman apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation
Extracellular matrix (ECM) assembly/disassembly is a critical regulator for airway epithelial development and remodeling. Airway organoid is widely used in respiratory research, yet there is limited study to i...
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Open AccessSCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity
CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC (hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we perform a metabolic gene CRISPR/Cas9...
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Open AccessThe implications for potential marginal land resources of cassava across worldwide under climate change challenges
The demand for energy plants is foreseen to grow as worldwide energy and climate policies promote the use of bioenergy for climate change mitigation. To avoid competing with food production, it’s critical to a...
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Open AccessSpatial–temporal distribution of global production–living–ecological space during the period 2000–2020
Global production-living-ecology space closely corresponds with sustainable development’s economic, social and ecological elements. The dataset of global production–living–ecological space in this paper was ge...
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Open AccessAnthropogenic modifications: impacts and conservation strategies
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Open AccessMemory-dictated dynamics of single-atom Pt on CeO2 for CO oxidation
Single atoms of platinum group metals on CeO2 represent a potential approach to lower precious metal requirements for automobile exhaust treatment catalysts. Here we show the dynamic evolution of two types of sin...
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Open AccessExploring the global geography of cybercrime and its driving forces
Cybercrime is wreaking havoc on the global economy, national security, social stability, and individual interests. The current efforts to mitigate cybercrime threats are primarily focused on technical measures...
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Open AccessDetermining the potential distribution of Oryctes monoceros and Oryctes rhinoceros by combining machine-learning with high-dimensional multidisciplinary environmental variables
The African coconut beetle Oryctes monoceros and Asiatic rhinoceros beetle O. rhinoceros have been associated with economic losses to plantations worldwide. Despite the amount of effort put in determining the pot...
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Open AccessVarying climatic-social-geographical patterns shape the conflict risk at regional and global scales
Given that armed conflict has been seriously impeding sustainable development, reducing the frequency and intensity of armed conflicts has become an explicit goal and a common theme of the 2030 Sustainable Dev...
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Open AccessModelling armed conflict risk under climate change with machine learning and time-series data
Understanding the risk of armed conflict is essential for promoting peace. Although the relationship between climate variability and armed conflict has been studied by the research community for decades with q...
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Open AccessComputational optical sectioning with an incoherent multiscale scattering model for light-field microscopy
Quantitative volumetric fluorescence imaging at high speed across a long term is vital to understand various cellular and subcellular behaviors in living organisms. Light-field microscopy provides a compact co...
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Open AccessA solution-processable and ultra-permeable conjugated microporous thermoset for selective hydrogen separation
The synthesis of a polymer that combines the processability of plastics with the extreme rigidity of cross-linked organic networks is highly attractive for molecular sieving applications. However, cross-linked...
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Open AccessEfficient travelling-mode quantum key agreement against participant’s attacks
Quantum key agreement (QKA) is to negotiate a final key among several participants fairly and securely. In this paper, we show that some existing travelling-mode multiparty QKA protocols are vulnerable to inte...
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Open AccessBerberine inhibits adipocyte differentiation, proliferation and adiposity through down-regulating galectin-3
This study is designed to investigate the effects of berberine (BBR) on galectin-3 (Gal-3) and the relationships to its suppressive activities on adipocyte differentiation, proliferation and adiposity. Our res...
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Open AccessLiver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
Cardiovascular and metabolic disease (CMD) remains a main cause of premature death worldwide. Berberine (BBR), a lipid-lowering botanic compound with diversified potency against metabolic disorders, is a promi...
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Open AccessMap** the Potential Global Codling Moth (Cydia pomonella L.) Distribution Based on a Machine Learning Method
The spread of invasive species may pose great threats to the economy and ecology of a region. The codling moth (Cydia pomonella L.) is one of the 100 worst invasive alien species in the world and is the most dest...
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Open AccessThe Radiated Deep-frozen Xenogenic Meniscal Tissue Regenerated the Total Meniscus with Chondroprotection
Meniscal allograft transplantation yields good and excellent results but is limited by donor availability. The purpose of the study was to evaluate the effectiveness of radiated deep-frozen xenogenic meniscal ...
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Open AccessPhysiological and biochemical changes during drought and recovery periods at tillering and jointing stages in wheat (Triticum aestivum L.)
Defining the metabolic strategies used by wheat to tolerate and recover from drought events will be important for ensuring yield stability in the future, but studies addressing this critical research topic are...
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Open AccessCorrection: Corrigendum: Soil warming enhances the hidden shift of elemental stoichiometry by elevated CO2 in wheat
Scientific Reports 6: Article number: 23313; published online: 22 March 2016; updated: 22 December 2017. The authors neglected to cite two previous studies related to the effect of elevated CO2 on minerals. Th...
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Open AccessDual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity
Autophagy and immune response are two defense systems that human-body uses against viral infection. Previous studies documented that some viral mechanisms circumvented host immunity mechanisms and hijacked aut...