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Open AccessApplication of downhole throttling technology to mitigate sustained casing pressure
Sustained casing pressure (SCP) and/or annular pressure build-up (APB) can pose severe threats to the safe operation of high-pressure, high-production gas wells, leading to premature well abandonment, unplanne...
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Open AccessUpper limit estimate to wellhead flowing pressure and applicable gas production for a downhole throttling technique in high-pressure–high-temperature gas wells
In recent years, China has explored and exploited several high-pressure deep gas fields. Normally, high-pressure gas wells are gathered and processed through multichoke manifolds on well sites, creating hazard...
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Open AccessComparative transcriptome revealed the molecular responses of Aconitum carmichaelii Debx. to downy mildew at different stages of disease development
Aconitum carmichaelii Debx. has been widely used as a traditional medicinal herb for a long history in China. It is highly susceptible to various dangerous diseases during the cultivation process. Downy mildew is...
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Open AccessGenetic alterations and allele frequency of BRAF V600E and TERT mutation in papillary thyroid carcinoma with intermediate-to-high recurrence risk: a retrospective study
The predictive value of allele frequency (AF) of BRAF V600E and TERT mutations in papillary thyroid carcinoma (PTC) remains controversial. We aimed to investigate the AF of BRAF V600E and TERT mutations in interm...
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Observational analysis of the immunogenicity and safety of various types of spinal muscular atrophy vaccines
This study aimed to evaluate the immunogenicity and safety of different types of poliovirus vaccines.
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Open AccessComparison of the effectiveness of two adjustable negative pressure ureteral access sheaths combined with flex ureteroscopy for ≤ 2 cm renal stones
To compare the safety and effectiveness of the combination of intelligent intrarenal pressure control platforms (IPCP) and flexible ureteral access sheath (FUAS) combined with retrograde intrarenal surgery (RI...
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Open AccessHRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion
Intestinal ischemia/reperfusion (I/R) injury is a typical pathological course in the clinic with a high morbidity rate. Recent research has pointed out the critical role of ubiquitination during the occurrence...
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Efficient degradation of cellulosic ethanol wastewater by perovskite activation of Sr element A-site doped lanthanide copper chalcogenide materials
The degradation of cellulosic ethanol wastewater by peroxymonosulfate (PMS) is one of the important methods to solve the environmental problems caused by it. In order to improve the degradation efficiency of c...
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Isolation and identification of two pathogens causing leaf spot of Fritillaria taipaiensis P. Y. Li. in China
Fritillaria taipaiensis P. Y. Li is one of the biological sources for Fritillariae Cirrhosae Bulbus. Its bulbs are widely used for treating respiratory diseases such as pneumonia, bronchitis and influenza. Cultiv...
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Two-stage generative adversarial networks for metal artifact reduction and visualization in ablation therapy of liver tumors
The strong metal artifacts produced by the electrode needle cause poor image quality, thus preventing physicians from observing the surgical situation during the puncture process. To address this issue, we pro...
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Open AccessExpression of TXLNA in brain gliomas and its clinical significance: a bioinformatics analysis
To analyze the expression of TXLNA in brain gliomas and its clinical significance.
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Open AccessSUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways
Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus hypersecretion that contribute to the morbidity and mortality of this disease. Here, we explore the potential role and underlying...
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A2O-MBR-BAF-O3 process for treating fractory domestic sewage mixed with industrial sewage
The seriously polluted water environment leads to a high level of refractory organic matter in the water intake of some sewage treatment plants.To solve the vexed water pollution, the anaerobic-anoxic-aerobic (A2
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Real-Time Navigation with Guide Template for Pedicle Screw Placement Using an Augmented Reality Head-Mounted Device: A Proof-of-Concept Study
This study aims to explore the real-time navigation with guide template using an augmented reality head-mounted device (ARHMD) for pedicle screw placement.
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Morphometric change in intervertebral foramen after percutaneous endoscopic lumbar foraminotomy: an in vivo radiographic study based on three-dimensional foramen reconstruction
This study aimed to perform in vivo three-dimensional (3D) quantitative measurements of morphometric changes in the foramen in patients with lumbar foraminal stenosis (LFS) undergoing percutaneous endoscopic l...
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Open AccessPromising therapeutic aspects in human genetic imprinting disorders
Genomic imprinting is an epigenetic phenomenon of monoallelic gene expression pattern depending on parental origin. In humans, congenital imprinting disruptions resulting from genetic or epigenetic mechanisms ...
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Composite hydrolytic acidification - aerobic MBBR process for treating traditional Chinese medicine wastewater
Traditional Chinese medicine (TCM) wastewater is characterized by high organic content, unstable water quality and quantity and low biodegradability. In this paper, the hydrolytic acidification reactor—aerobic...
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Open AccessAuthor Correction: Artificial intelligence defines protein-based classification of thyroid nodules
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Open AccessArtificial intelligence defines protein-based classification of thyroid nodules
Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility of develo** an AI-defined protein-based biomarker panel for diagnostic...
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Open AccessMitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury
Apoptosis is a critical event in the pathogenesis of lung ischemia/reperfusion (I/R) injury. Sirtuin 3 (SIRT3), an important deacetylase predominantly localized in mitochondria, regulates diverse physiological...