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  1. Article

    Open Access

    Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament

    Ossification of the posterior longitudinal ligament (OPLL) is a disabling disease whose pathogenesis is still unclear, and there are no effective cures or prevention methods. Exosomal miRNA plays an important ...

    Yifan Tang, Yanqing Sun, Junkai Zeng, Bo Yuan, Yin Zhao in Journal of Nanobiotechnology (2022)

  2. Article

    Open Access

    Factors affecting titanium mesh cage subsidence in single-level anterior cervical corpectomy and fusion for ossification of the posterior longitudinal ligament

    To analyze risk factors of titanium mesh cage (TMC) subsidence in single-level anterior cervical corpectomy and fusion (ACCF) for cervical ossification of the posterior longitudinal ligament (OPLL).

    Yifan Tang, **angwu Geng, Fengning Li in Journal of Orthopaedic Surgery and Research (2022)

  3. Article

    Open Access

    Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling

    To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia–reperfusion injury (SCIRI) in mice and determine whether SIRT3 is involved in this protection and ...

    Changjiang Gu, Fanqi Kong, Junkai Zeng, **angwu Geng, Yanqing Sun in Cell & Bioscience (2023)

  4. Article

    Open Access

    Integrin αVβ3 antagonist-c(RGDyk) peptide attenuates the progression of ossification of the posterior longitudinal ligament by inhibiting osteogenesis and angiogenesis

    Ossification of the posterior longitudinal ligament (OPLL), an emerging heterotopic ossification disease, causes spinal cord compression, resulting in motor and sensory dysfunction. The etiology of OPLL remain...

    **angwu Geng, Yifan Tang, Changjiang Gu, Junkai Zeng, Yin Zhao in Molecular Medicine (2024)