17 Result(s)
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Article
**ang-Jun Ye
Biomedicine
Biomedicine, general
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Article
Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the effects of FMT on diabetes-associated cognitive defects in mic...
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ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the olfactory bulb (OB) ...
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The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown...
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Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B
Grincamycins (GCNs) are a class of angucycline glycosides isolated from actinomycete Streptomyces strains that have potent antitumor activities, but their antitumor mechanisms remain unknown. In this study, we tr...
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Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis
Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cell...
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Open AccessIncreased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis
The prognostic value of Ki-67 expression in colorectal cancer patients was controversial. Therefore, this meta analysis was conducted to ascertain the prognostic value of Ki-67 expression in colorectal cancer ...
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Open AccessAttributable causes of colorectal cancer in China
Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of color...
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Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation
Rivaroxaban is a new oral anticoagulant for stroke prevention in patients with non-valvular atrial fibrillation (NVAF), which has less drug–food interaction than warfarin. We conducted this prospective randomi...
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Open AccessExpression of AE1/p16 promoted degradation of AE2 in gastric cancer cells
Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl−/HCO3 − across the plasma membrane and regulate intracellular pH (pHi). AE1 is specifically expressed on the surfa...
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The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
The gut and oral microbiomes are altered in individuals with rheumatoid arthritis, and these changes can be used to stratify individuals for diagnostic and prognostic purposes.
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Open AccessB-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells
B-cell lymphoma 6 (BCL6) protein, an evolutionarily conserved zinc finger transcription factor, showed to be highly expressed in various human cancers in addition to malignancies in the lymphoid system. This s...
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Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo
20(S)-Ginsenoside Rh2 (Rh2) has shown potent inhibition on P-glycoprotein (P-gp), while most HIV protease inhibitors are both substrates and inhibitors of P-gp and CYP3A4. The aim of this study was to investigate...
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Neurochip based on light-addressable potentiometric sensor with wavelet transform de-noising
Neurochip based on light-addressable potentiometric sensor (LAPS), whose sensing elements are excitable cells, can monitor electrophysiological properties of cultured neuron networks with cellular signals well...
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Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases
To characterize and compare the different biological behaviors of 2 novel human osteosarcoma cell lines, Zos and Zos-M, established respectively from the primary tumor and the skip metastasis of an osteosarcom...
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Article
Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines
Comparative proteomics provide a powerful approach in screening for alterations in protein levels and post-translational modifications that are associated with tumors. In the present study, we aimed to identif...
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Article
Evaluation of organ distribution of microcystins in the freshwater phytoplanktivorous fish Hypophthalmichthys molitrix
To evaluate the public health risk of exposure to microcystins in fish food in China, the distribution pattern of microcystin-LR and microcystin-RR in various organs (liver, intestine, kidney, muscle and lipid...
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Article
Species diversity of Lachnum (Helotiales, Hyaloscyphaceae) from temperate China
Twenty-three temperate China species of Lachnum, Lachnum abnorme, L. angustum, L. brevipilosum, L. calosporum, L. calyculiforme, L. carneolum, L. ciliare, L. controversum, L. flavidulum, L. cf. fushanese, L. indi...
