93 Result(s)

Article

Neuropeptide natalisin regulates reproductive behaviors in Spodoptera frugiperda

Natalisin (NTL) is a conserved neuropeptide, only present in insects, that has been reported to regulate their sexual activity. In this study, we investigated the involvement of NTL in the reproductive behavio...

Wei Gong, Jun-Hong Linghu, Hui-Min Xu, Li-Lin Luo, Guy Smagghe… in Scientific Reports (2024)

Article

Author Correction: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways

Qi-wen Han, Qian-hang Shao, **ao-tong Wang, Kai-li Ma… in Acta Pharmacologica Sinica (2024)

Article

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...

**u-chun Li, **a-yan Zhu, Yang-yue Wang, Shuo-lan Tong… in Acta Pharmacologica Sinica (2024)

Article

Correction: Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data

Qunying Fang, Zonghui Qiao, Lei Luo, Shun Bai… in Reproductive Biology and Endocrinology (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data

The objective was to construct a model for predicting the probability of recurrent implantation failure (RIF) after assisted reproductive technology (ART) treatment based on the clinical characteristics and ro...

Qunying Fang, Zonghui Qiao, Lei Luo, Shun Bai… in Reproductive Biology and Endocrinology (2024)

Article

Global fungal-host interactome map** identifies host targets of candidalysin

Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...

Tian-Yi Zhang, Yao-Qi Chen, **g-Cong Tan, **-An Zhou… in Nature Communications (2024)

Article

Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets

The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. He...

Jun-Hong **ng, Tian-Ming Niu, Bo-Shi Zou, Gui-Lian Yang, Chun-Wei Shi… in Microbiome (2024)

Article

Gut microbiome for predicting immune checkpoint blockade-associated adverse events

The impact of the gut microbiome on the initiation and intensity of immune-related adverse events (irAEs) prompted by immune checkpoint inhibitors (ICIs) is widely acknowledged. Nevertheless, there is inconsis...

Muni Hu, **aolin Lin, Tiantian Sun, **aoyan Shao, **aowen Huang… in Genome Medicine (2024)

Article

Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

It remains controversial whether the long-term use of statins or newer nonstatin drugs has a positive effect on human longevity. Therefore, this study aimed to investigate the genetic associations between diff...

Han Chen, **aoying Zhou, **gwen Hu, Shuo Li, Zi Wang… in Lipids in Health and Disease (2023)

Article

EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances

The discovery and utilization of natural products derived from endophytic microorganisms have garnered significant attention in pharmaceutical research. While remarkable progress has been made in this field ea...

Hong-Quan Xu, Huan **ao, **-Hui Bu, Yan-Feng Hong… in Journal of Cheminformatics (2023)

Article

Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive und...

Lijun Ning, Yi-Lu Zhou, Han Sun, Youwei Zhang, Chaoqin Shen… in Nature Communications (2023)

Article

SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders

Protein-protein interactions (PPIs) are critical for biological processes and predicting the sites of these interactions is useful for both computational and experimental applications. We present a Structure-agno...

Garyk Brixi, Tianzheng Ye, Lauren Hong, Tian Wang… in Communications Biology (2023)

Article

Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method

Batch effects are notoriously common technical variations in multiomics data and may result in misleading outcomes if uncorrected or over-corrected. A plethora of batch-effect correction algorithms are propose...

Ying Yu, Naixin Zhang, Yuanbang Mai, Luyao Ren, Qiaochu Chen, Zehui Cao… in Genome Biology (2023)

Article

Assessment of rehabilitation following subarachnoid haemorrhage in China: findings from the Chinese Stroke Center Alliance

Rehabilitation improves functional recovery in subarachnoid hemorrhage (SAH) patients, and assessing patients for rehabilitation is the first step in this process. However, little is known about clinical pract...

Yi-Tong Chen, Mei-Ru Wu, Zi-**ao Li, Hong-Qiu Gu, Qi Zhou, Dan-Dan Wang… in BMC Neurology (2023)

Article

First report of mulberry vein banding-associated virus infecting Nicotiana tabacum in China

Ning Jiang, Tian-hua Han, Xue-biao Yang, Can-hua Lu… in Journal of Plant Pathology (2023)

Article

Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Generating reference maps of interactome networks illuminates genetic studies by providing a protein-centric approach to finding new components of existing pathways, complexes, and processes. We apply state-of...

Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao… in Nature Communications (2023)

Article

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019 (COVID-19) severity and lethality. However, drugs that are effective agai...

Lin **a, Lun-zhi Yuan, Ya-hong Hu, Jun-yi Liu… in Cellular & Molecular Immunology (2023)

Article

Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure

Heart failure (HF) patients in general have a higher risk of develo** cancer. Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression, highlighting a caus...

Ye Yuan, Zhongting Mei, Zhezhe Qu, Guanghui Li… in Signal Transduction and Targeted Therapy (2023)

Article

Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection

Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of ...

Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen… in Nature Communications (2023)