43 Result(s)
within
Article
**an-Sheng Jia
Life Sciences
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Article
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Despite its crucial role in the regulation of vital metabolic and neurological functions, the genetic architecture of the hypothalamus remains unknown. Here we conducted multivariate genome-wide association st...
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Open AccessADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
Hyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown...
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Entomopathogenic fungal-derived metabolites alter innate immunity and gut microbiota in the migratory locust
There are complex temporal and spatial interactions between insects and microbes. Previously, the function of microbial virulence factors has been identified and characterized. However, the roles of disease-re...
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Open AccessBiogeographic patterns of meio- and micro-eukaryotic communities in dam-induced river-reservoir systems
Although the Three Gorges Dam (TGD) is the world’s largest hydroelectric dam, little is known about the spatial–temporal patterns and community assembly mechanisms of meio- and micro-eukaryotes and its two sub...
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CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma
The roles of cyclin-dependent kinase 6 (CDK6) in various cancers, including small cell lung carcinoma (SCLC), remain unclear. Here, 111,54 multi-center samples were investigated to determine the expression, clini...
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Open AccessHSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation
Ultra-stable fibrous structure is a hallmark of amyloids. In contrast to canonical disease-related amyloids, emerging research indicates that a significant number of cellular amyloids, termed ‘functional amylo...
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Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...
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Characterization of a novel tetravalent botulism antitoxin based on receptor-binding domain of BoNTs
Botulinum neurotoxin (BoNTs; serotypes A, B, E, and F) cause botulism disease in humans, which could be effectively treated using antitoxins. Herein, we established a novel receptor-binding domain (RBD)-based ...
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Bacteriophage-based techniques for elucidating the function of zebrafish gut microbiota
Bacteriophages (or phages) are unique viruses that can specifically infect bacteria. Since their discovery by Twort and d’Herelle, phages with bacterial specificity have played important roles in microbial reg...
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Morphological characteristics, anatomical structure, and dynamic change of ascorbic acid under different storage conditions of celery
Ascorbic acid (AsA) is a crucial antioxidant in vegetables. Celery (Apium graveolens L.) is a vegetable of Apiaceae and is rich in AsA. Till now, the effects of different storage conditions on celery morphologica...
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Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Open AccessExosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4
Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-...
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Open AccessA novel somatosensory spatial navigation system outside the hippocampal formation
Spatially selective firing of place cells, grid cells, boundary vector/border cells and head direction cells constitutes the basic building blocks of a canonical spatial navigation system centered on the hippo...
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Genetic linkage map construction and quantitative trait loci map** of agronomic traits in Gloeostereum incarnatum
Gloeostereum incarnatum is an edible medicinal mushroom widely grown in China. Using the whole genome of G. incarnatum, simple sequence repeat (SSR) markers were developed and synthetic primers were designed to c...
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Author Correction: 863 genomes reveal the origin and domestication of chicken
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open Access863 genomes reveal the origin and domestication of chicken
Despite the substantial role that chickens have played in human societies across the world, both the geographic and temporal origins of their domestication remain controversial. To address this issue, we analy...
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Deacetylation of chitin oligomers increases virulence in soil-borne fungal pathogens
Soil-borne fungal pathogens that cause crop disease are major threats to agriculture worldwide. Here, we identified a secretory polysaccharide deacetylase (PDA1) from the soil-borne fungus Verticillium dahliae, t...
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Open AccessOsteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin
The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide in recent decades. Osteopontin (OPN) plays an important role in cancer metastasis, but its functional mechanism in ...
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Effects of a bacterial consortium from acid mine drainage on cadmium phytoextraction and indigenous soil microbial community
A major concern in develo** microbially-assisted phytoextraction (MAP) is that the effects of introduced microbes on indigenous soil microbial community are profound and irreversible. To date, however, the m...
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Type 1 metallothionein (ZjMT) is responsible for heavy metal tolerance in Ziziphus jujuba
Metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, metal-binding proteins that are able to make cells to uptake heavy metals from the environment. Molecular and functional characteriza...
