141 Result(s)

Article

Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury

Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-d-aspartate receptor)-dependent cell death pathways in stroke^1,2, but unsuccessful clinical trials with NMDAR antagonists impli...

Ke Lai, Iva Pritišanac, Zhen-Qi Liu, Han-Wei Liu, Li-Na Gong, Ming-**an Li… in Nature (2024)

Article

Transcutaneous Electrical Acupoint Stimulation Combined with Moderate Sedation of Remimazolam Tosilate in Gastrointestinal Endoscopy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Further clinical validation is required to determine whether transcutaneous electrical acupoint stimulation (TEAS) can replace opioids and be used in combination with remimazolam for sedation during gastrointe...

Jian-Han Xu, Hai-Ling Tan, Li-Na Zhang, Zan-Gong Zhou, Li Yuan… in Pain and Therapy (2024)

Article

Retraction Note: FoxM1-mediated RFC5 expression promotes temozolomide resistance

Wan-xin Peng, **u Han, Chun-li Zhang, Lu Ge, Feng-yi Du… in Cell Biology and Toxicology (2024)

Article

Anti-inflammatory properties and characterization of water extracts obtained from Callicarpa kwangtungensis Chun using in vitro and in vivo rat models

Callicarpa kwangtungensis Chun (CK) is a common remedy exhibits anti-inflammatory properties and has been used in Chinese herbal formulations, such as KangGongYan tablets. It is the main component of KangGongYan ...

Jun-Jian Li, Li Li, Shan-Shan Su, Mei-Lan Liao, Qiu-Zi Gong, Mei Liu… in Scientific Reports (2024)

Article

Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts

SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care.

Yuan-Yuan Pei, Hong-Li Wang, Gen-Quan Yin, Yi Xu… in World Journal of Pediatrics (2024)

Article

Artificial intelligence in the risk prediction models of cardiovascular disease and development of an independent validation screening tool: a systematic review

A comprehensive overview of artificial intelligence (AI) for cardiovascular disease (CVD) prediction and a screening tool of AI models (AI-Ms) for independent external validation are lacking. This systematic r...

Yue Cai, Yu-Qing Cai, Li-Ying Tang, Yi-Han Wang, Mengchun Gong… in BMC Medicine (2024)

Article

Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....

Ting-Ting Gong, Shuang Guo, Fang-Hua Liu, Yun-Long Huo, Meng Zhang… in Nature Communications (2023)

Article

Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism

Apart from cancer, metabolic reprogramming is also prevalent in other diseases, such as bacterial infections. Bacterial infections can affect a variety of cells, tissues, organs, and bodies, leading to a serie...

**ao-yue Li, Zi-xin Zeng, Zhi-xing Cheng, Yi-lin Wang, Liang-Jun Yuan… in Amino Acids (2023)

Article

Composition of pathogenic microorganism in chronic osteomyelitis based on metagenomic sequencing and its application value in etiological diagnosis

Traditionally, conventional microbiological culture methods have been used to detect pathogenic microorganisms in chronic osteomyelitis. However, these methods have been found to have a low detection rate, com...

Kang Zhang, Yu-zhe Bai, Chang Liu, Shan-shan Liu, **n-xin Lu… in BMC Microbiology (2023)

Article

Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese ...

Xu Lin, Hong-Mei **ao, Hui-Min Liu, Wan-Qiang Lv… in Nature Communications (2023)

Article

CD24⁺LCN2⁺ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury

CD24⁺CK19⁺/CD24⁺SOX9⁺ resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.

Wei-Jian Huang, Bi-Jun Qiu, **ao-Shu Qi, Cai-Yang Chen, Wen-Ming Liu… in Cell & Bioscience (2023)

Article

Value of Echocardiography and Cardiac Magnetic resonance in assessing left ventricular function in breast and gastric cancer patients after Anthracycline Chemotherapy

Echocardiography (ECHO) and cardiac magnetic resonance imaging (MRI) are used to observe changes in the left ventricular structure in patients with breast and gastric cancer after 6 cycles of chemotherapy. Bas...

Chao-long **, Xue-gong Shi, Ting-ting Wang, Hong-wen Li… in BMC Cardiovascular Disorders (2023)

Article

FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis

Family with sequence similarity three member (FAM3) plays a crucial role in the malignant development of various cancers of human. However, there remains doubtful what specific role of FAM3 family genes in pan...

Qing-Tai Dong, Dan-Dan Ma, Qi Gong, Zhen-Yu Lin, Zhong-Hu Li… in Scientific Reports (2023)

Article

Effect of lifestyle or metformin interventions before IVF/ICSI treatment on infertile women with overweight/obese and insulin resistance: a factorial design randomised controlled pilot trial

For infertile women with overweight/obesity and insulin resistance (IR), it is uncertain whether intervention before infertility treatment can improve live birth rate (LBR). We implemented a factorial-design s...

**aojuan Wang, Sufen Cai, Sha Tang, Lanlin Yang, **g Tan… in Pilot and Feasibility Studies (2023)

Article

A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong genetic liability. Despite extensive studies, however, the underlying pathogenic mechanism still remains elusive. In the ...

Yongyi Li, Mingwei Zhu, Wen-**ong Chen, **g Luo, **n Li… in Molecular Psychiatry (2023)

Article

A longitudinal resource for population neuroscience of school-age children and adolescents in China

During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...

Xue-Ru Fan, Yin-Shan Wang, Da Chang, Ning Yang, Meng-Jie Rong, Zhe Zhang… in Scientific Data (2023)

Article

Cross-sectional study of characteristics of body composition of 24,845 children and adolescents aged 3–17 years in Suzhou

We aimed to analyze the characteristics of the body composition of children and adolescents aged 3–17 in Suzhou, China.

Yan Zhao, **-xin Gong, Yi-ting Ji, **ao-yun Zhao, Lu He, Shi-zhong Cai… in BMC Pediatrics (2023)

Article

Hyperbolic polaritonic crystals with configurable low-symmetry Bloch modes

Photonic crystals (PhCs) are a kind of artificial structures that can mold the flow of light at will. Polaritonic crystals (PoCs) made from polaritonic media offer a promising route to controlling nano-light a...

Jiangtao Lv, Yingjie Wu, **gying Liu, Youning Gong, Guangyuan Si… in Nature Communications (2023)

Article

Discovery of extracellular vesicle-delivered miR-185-5p in the plasma of patients as an indicator for advanced adenoma and colorectal cancer

We aimed to evaluate whether extracellular vesicles (EV)-derived microRNAs (miRNAs) can be used as biomarkers for advanced adenoma (AA) and colorectal cancer (CRC).

Yun-Jie Shi, Yu-**ang Fang, Tong-Guan Tian… in Journal of Translational Medicine (2023)

Article

Absence of critical thickness for polar skyrmions with breaking the Kittel’s law

The period of polar domain (d) in ferroics was commonly believed to scale with corresponding film thicknesses (h), following the classical Kittel’s law of d ∝

Feng-Hui Gong, Yun-Long Tang, Yu-Jia Wang, Yu-Ting Chen, Bo Wu… in Nature Communications (2023)