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    Article

    Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice

    Recent pre-clinical and clinical studies suggest that general anesthesia in infants and children may increase the risk of learning disabilities. Currently, there is no treatment for preventing anesthesia-induc...

    Chun-Ling Dai, Hengchang Li, **n Hu, ** Zhang, Fei Liu… in Neurotoxicity Research (2020)

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    Article

    Alzheimer neurofibrillary degeneration

    Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this lesion offers a promising therapeutic approach. The ...

    Khalid Iqbal, Alejandra del C. Alonso, Ezzat El-Akkad… in Journal of Molecular Neuroscience (2003)

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    Article

    Significance and mechanism of alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

    Abnormally hyperphosphorylated tau which is the major protein subunit of paired helical filaments (PHF)/neurofibrillary tangles is the pivotal lesion in Alzheimer disease (AD) and related tauopathies. The cose...

    Khalid Iqbal, Alejandra del C. Alonso, Ezzat El-Akkad… in Journal of Molecular Neuroscience (2002)

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    Article

    Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Nonbinding Phosphatase Activities

    Phosphatases extracted from a human brain were resolved into two main groups, namely affi-gel blue-binding phosphatases and affi-gel blue-nonbinding phosphatases. Affi-gel blue binding phosphatases were furthe...

    Li Yao Cheng, Jian-Zhi Wang, Cheng-**n Gong, **-**g Pei… in Neurochemical Research (2001)

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    Article

    Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Binding Phosphatases

    Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel w...

    Li Yao Cheng, Jian-Zhi Wang, Cheng-**n Gong, **-**g Pei… in Neurochemical Research (2000)