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  1. Article

    Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

    The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic indivi...

    Quan-**n Long, **ao-Jun Tang, Qiu-Lin Shi, Qin Li, Hai-Jun Deng… in Nature Medicine (2020)

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  2. Article

    Antibody responses to SARS-CoV-2 in patients with COVID-19

    We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...

    Quan-**n Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-Cheng Wu, Kun Deng… in Nature Medicine (2020)

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    Article

    Wang et al. reply

    Pi-**ao Wang, Guang-Nian Zhao, Yan-**ao Ji, Peng Zhang, **ao-**g Zhang… in Nature Medicine (2018)

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    Article

    The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

    The deubiquitinase CYLD regulates a TAK1–JNK pathway and can be targeted to ameliorate nonalcoholic steatohepatitis.

    Yan-**ao Ji, Zan Huang, **a Yang, **aozhan Wang, Ling-** Zhao… in Nature Medicine (2018)

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    Article

    The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

    The deubiquitinase TNFAIP3 suppresses the kinase ASK1 to ameliorate nonalcoholic fatty liver disease.

    Peng Zhang, Pi-**ao Wang, Ling-** Zhao, **n Zhang, Yan-**ao Ji… in Nature Medicine (2018)

  6. Article

    Correction: Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

    Nat. Med. 23, 439–449 (2017); published online 20 February 2017; corrected after print 26 July 2017 In the version of this article initially published, the authors inadvertently left out information in the Onl...

    Pi-**ao Wang, Yan-**ao Ji, **ao-**g Zhang, Ling-** Zhao… in Nature Medicine (2017)

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    Article

    Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

    Toll-like receptor (TLR) 4 is a key mediator of non-alcoholic fatty liver disease progression. Targeting TLR4 degradation via the lysosome pathway improves outcome in mouse and monkey models of this condition.

    Guang-Nian Zhao, Peng Zhang, Jun Gong, **ao-**g Zhang, Pi-**ao Wang… in Nature Medicine (2017)

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    Article

    Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

    Targeting CFLAR in mouse and non-human primates ameliorates non-alcoholic steatohepatitis by decreasing JNK signaling in hepatocytes.

    Pi-**ao Wang, Yan-**ao Ji, **ao-**g Zhang, Ling-** Zhao… in Nature Medicine (2017)

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    Article

    Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer

    Downregulation of estrogen receptor-α (ER-α) in breast tumors can mediate resistance to ER-α–targeted therapies such as tamoxifen. This report sheds light on a therapy resistance–conferring adaptation by ident...

    **n Pan, Tao Zhou, Yan-Hong Tai, Chenguang Wang, Jie Zhao, Yuan Cao… in Nature Medicine (2011)