46 Result(s)
within
Neurology
Psychiatry
**-li Lu
Article
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Article
Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture
Formation of neurofibrillary tangle from hyperphosphorylated tau is one of the hallmark lesions seen in Alzheimer’s disease (AD) brain, and neuronal deregulation of glycogen synthase kinase-3 (GSK-3) activity ...
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Poster abstracts
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Article
Spinocerebellar ataxia type 11 in the Chinese Han population
The spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative diseases. Researchers have recently found that SCA type 11 (SCA11) is associated with mutations in the
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Structures and connections of enkephalin- and γ-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study
GABA and enkephalin (ENK) are principle inhibitory transmitters in the rostral portion of the nucleus tractus solitarius (rNTS) for regulating the gustatory information. Although the existence of GABA- and ENK...
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Melatonin protects mice with intermittent hypoxia from oxidative stress-induced pancreatic injury
One of the most important mechanisms linking obstructive sleep apnea (OSA) to insulin resistance and type 2 diabetes involves oxidative stress. We examined whether oxidative stress-induced pancreatic injury co...
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Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
Although the increased prevalence of Parkinson’s disease (PD) with aging suggests that aging processes predispose dopamine neurons to degeneration, the mechanism involved remains unknown. Dopamine neurons cont...
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An Event-Related Potential Study of Maternal Love in Mothers
Feeling is stable and implicit and can be explicated in concrete situations in the form of emotion. To map the time course of feeling processing, the present study explored electrophysiological responses relev...
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Association between interleukin-1α C(−889)T polymorphism and Alzheimer’s disease: a meta-analysis including 12,817 subjects
Epidemiological studies have evaluated the association between interleukin-1 (IL-1)α C(−889)T polymorphism and Alzheimer’s disease (AD), but the results remain inconclusive. This meta-analysis was, therefore, ...
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Open AccessBAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects
Attention-deficit/hyperactivity disorder (ADHD) is a common chronic neurodevelopmental disorder with a high heritability. Much evidence of hemisphere asymmetry has been found for ADHD probands from behavioral ...
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A model of synaptic plasticity: activation of mGluR I induced long-term theta oscillations in medial septal diagonal band of rat brain slice
This study aimed to establish a model of synaptic plasticity by the activation of metabotropic glutamate receptor (mGluR) I in rat medial septal diagonal band (MSDB). Electrophysiological experiment was perfor...
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Open AccessAutism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits
As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to...
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Connections between EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn
Endomorphin-2 (EM2) demonstrates a potent antinociceptive effect in pain modulation. To investigate the potential interactions of EM2- and substance P (SP)-containing primary afferents and γ-amino butyric acid...
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Identifying the role of microRNAs in spinal cord injury
Spinal cord injury (SCI) is medically and socioeconomically debilitating, and effective treatments are lacking. The elucidation of the pathophysiological mechanisms underlying SCI is essential for develo** e...
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Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were ...
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Association of three candidate genetic variants in RAB7L1/NUCKS1, MCCC1 and STK39 with sporadic Parkinson’s disease in Han Chinese
Previous studies identified that polymorphisms RAB7L1/NUCKS1 rs823118, MCCC1 rs12637471 and STK39 rs1955337 to be the risk loci for Parkinson’s disease (PD) in a Caucasian population. However, the characteristics...
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Rapidly progressive neurological deterioration in anti-AMPA receptor encephalitis with additional CRMP5 antibodies
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis positive for additional onconeural antibodies is rarely reported. Here we report the clinical features of a patient who d...
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Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease
Parkinson’s disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth (SIBO). The aim of the study was to assess the preva...
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Genetic association study between RIT2 and Parkinson’s disease in a Han Chinese population
Recent several meta-analyses and certain case–control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson’s disease (PD) in Asian and Caucasian populations. Howeve...
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The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects
The association between ALOX5AP SG13S114 polymorphism and ischemic stroke (IS) susceptibility has extensively been investigated, especially in white populations; however, the results were inconclusive. Here, w...
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Open AccessPrior Visual Experience Modulates Learning of Sound Localization Among Blind Individuals
Cross-modal learning requires the use of information from different sensory modalities. This study investigated how the prior visual experience of late blind individuals could modulate neural processes associa...
