156 Result(s)

Article

Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models

Autophagy impairment is a key factor in Alzheimer’s disease (AD) pathogenesis. TFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM enhancer 3) are nuclear transcription factors that r...

**n-jie Guan, Zhi-qiang Deng, Jia Liu, Cheng-fu Su… in Acta Pharmacologica Sinica (2024)

Article

The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator

SCH23390 is a widely used D₁ dopamine receptor (D₁R) antagonist that also elicits some D₁R-independent effects. We previously found that the benzazepine, SKF83959, an analog of SCH23390, produces positive alloste...

Gu-fang Zhang, Kai-lian Zhu, Qi Li, Yue Zhang… in Acta Pharmacologica Sinica (2024)

Article

Reexamining the effects of drug loading on the in vivo performance of PEGylated liposomal doxorubicin

Higher drug loading employed in nanoscale delivery platforms is a goal that researchers have long sought after. But such viewpoint remains controversial because the impacts that nanocarriers bring about on bod...

Yi-fei Yu, Er-can Wu, Shi-qi Lin, Yu-xiu Chu, Yang Yang… in Acta Pharmacologica Sinica (2024)

Article

Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia

The metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa-induced pneumonia model, we reported that IL-10-producing B c...

Ying Fu, Baichao Yu, Qi Wang, Zhou Lu, Hushan Zhang… in Cellular & Molecular Immunology (2024)

Article

Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells

5-Fluorouracil (5-FU) is the first-line treatment for colorectal cancer (CRC) patients, but the development of acquired resistance to 5-FU remains a big challenge. Deubiquitinases play a key role in the protei...

Wa Ding, **-xiang Wang, Jun-zheng Wu, Ao-chu Liu… in Acta Pharmacologica Sinica (2023)

Article

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T_H17 cell immunity

Regulatory T cells (T_reg cells) are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which T_reg cells control a specific type of immune response in a given tissue ...

Chia-Hao Lin, Cheng-Jang Wu, Sunglim Cho, Rasika Patkar… in Nature Immunology (2023)

Article

A novel small-molecular CCR5 antagonist promotes neural repair after stroke

Chemokine receptor 5 (CCR5) is one of the main co-receptors of HIV-1, and has been found to be a potential therapeutic target for stroke. Maraviroc is a classic CCR5 antagonist, which is undergoing clinical tr...

Qing-lin Wu, Li-yuan Cui, Wen-yu Ma, Sha-sha Wang, Zhao Zhang… in Acta Pharmacologica Sinica (2023)

Article

A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis

The gut microbiome is recognized as a key modulator of sepsis development. However, the contribution of the gut mycobiome to sepsis development is still not fully understood. Here, we demonstrated that the lev...

Peng Gu, Ruofan Liu, Qin Yang, Li **e, Rongjuan Wei… in Cellular & Molecular Immunology (2023)

Article

Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy

Inhibition of NLRP3 inflammasome activation produces potent therapeutic effects in a wide array of inflammatory diseases. Bergapten (BeG), a furocoumarin phytohormone present in many herbal medicines and fruit...

Tong Luo, **n Jia, Wan-di Feng, **-yong Wang, Fang **e… in Acta Pharmacologica Sinica (2023)

Article

Combined targeting of CCL7 and Flt3L to promote the expansion and infiltration of cDC1s in tumors enhances T-cell activation and anti-PD-1 therapy effectiveness in NSCLC

Hong-Peng Dong, Ying Li, Zhen Tang, Peng Wang, Bo Zhong… in Cellular & Molecular Immunology (2023)

Article

Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling

Previous studies show that notoginsenoside R1 (NG-R1), a novel saponin isolated from Panax notoginseng, protects kidney, intestine, lung, brain and heart from ischemia-reperfusion injury. In this study we investi...

**g-**g Zeng, Han-qing Shi, Fang-fang Ren, … in Acta Pharmacologica Sinica (2023)

Article

CircRNA7632 down-regulation alleviates endothelial cell dysfunction in Kawasaki disease via regulating IL-33 expression

Kawasaki disease (KD) is a form of idiopathic vasculitis frequently accompanied by coronary artery lesions, which involves endothelial dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs...

Huixian Qiu, Chao Ni, Chang Jia, **ng Rong, Mao** Chu… in Cell Stress and Chaperones (2023)

Article

Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the develo** mouse brain

Normal sensory and cognitive function of the brain relies on its intricate and complex neural network. Synaptogenesis and synaptic plasticity are critical to neural circuit formation and maintenance, which are...

Guang-ying Li, Qiu-zi Wu, Tian-jia Song, Xue-chu Zhen… in Acta Pharmacologica Sinica (2023)

Article

Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Small-cell lung cancer (SCLC) is an aggressive high-grade neuroendocrine carcinoma of the lung associated with early metastasis and an exceptionally poor prognosis. Little progress has been made in develo** ...

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)