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Metabolic syndrome and its components in relation to brachial-ankle pulse wave velocity in middle-aged Taiwanese males
To evaluate the association of The study is to evaluate the association of metabolic syndrome (MS) and its components on brachial-ankle pulse wave velocity (baPWV), an indirect marker of subclinical atheroscle...
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Open AccessEBV meningoencephalitis accompanied with multifocal cerebral lesions
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Open AccessHuman herpesvirus-7 associated recurrent encephalitis in an immunocompetent young man and successful foscarnet treatment
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Open AccessIntraductal micro magnetic resonance imaging and spectroscopy
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Open AccessKinetics of neutralizing antibodies in patients naturally infected by H5N1 virus
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Open AccessMutational analysis of H5N1 hemagglutinins: identification of molecular determinants for efficient packaging into pseudotyped lentiviral particles
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Open AccessIdentification of functional genetic variation in exome sequence analysis
Recent technological advances have allowed us to study individual genomes at a base-pair resolution and have demonstrated that the average exome harbors more than 15,000 genetic variants. However, our ability ...
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AAV8-Mediated Long-Term Expression of Human LCAT Significantly Improves Lipid Profiles in hCETP;Ldlr+/− Mice
Lecithin:cholesterol acyltransferase (LCAT) is the key circulating enzyme responsible for high-density lipoprotein (HDL) cholesterol esterification, HDL maturation, and potentially reverse cholesterol transpor...
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Open AccessMicrobiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study
Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells. It has been shown that porc...
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Association Between Endothelial Nitric Oxide Synthase Polymorphisms and Atrial Fibrillation: A Meta-analysis
Several recent studies have focused on the association between the promoter polymorphisms 786T/C of the endothelial nitric oxide synthase (eNOS) gene and susceptibility to atrial fibrillation (AF); however, re...
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Open AccessEffectiveness of acupuncture intervention for neck pain caused by cervical spondylosis: study protocol for a randomized controlled trial
Neck pain caused by cervical spondylosis has become a common health problem worldwide among >40-year-old adults. Acupuncture intervention is one of the most popular treatment measures for this disorder. Howeve...
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Open AccessUrinary soluble urokinase receptor levels are elevated and pathogenic in patients with primary focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease. Recent studies have proposed that plasma soluble urokinase receptor (suPAR) might be a causative circulating factor but th...
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Open AccessAccounting for center in the Early External Cephalic Version trials: an empirical comparison of statistical methods to adjust for center in a multicenter trial with binary outcomes
Clustering of outcomes at centers involved in multicenter trials is a type of center effect. The Consolidated Standards of Reporting Trials Statement recommends that multicenter randomized controlled trials (R...
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Open AccessVisit-to-visit variability of fasting plasma glucose as predictor of ischemic stroke: competing risk analysis in a national cohort of Taiwan Diabetes Study
Glycemic variation as an independent predictor of ischemic stroke in type 2 diabetic patients remains unclear. This study examined visit-to-visit variations in fasting plasma glucose (FPG), as represented by t...
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Open AccessAssessing the effect of mutant JAM-A overexpression on downstream signalling in breast cancer cells
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Open AccessThe efficacy of electroacupuncture for the treatment of simple female stress urinary incontinence - comparison with pelvic floor muscle training: study protocol for a multicenter randomized controlled trial
Previous research has shown that electroacupuncture therapy has a potential therapeutic effect for simple female stress urinary incontinence. In this study, pelvic floor muscle training, the first-line treatme...
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Guidelines for Assessing Mouse Endothelial Function via Ultrasound Imaging: a Report from the International Society of Cardiovascular Translational Research
The study is to establish a novel method to determine the endothelial function in mouse carotid arteries in vivo by using high-resolution ultrasound images. Atherosclerosis in carotid arteries is induced in ApoE−...
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Open AccessThe effectiveness of the biannual application of silver nitrate solution followed by sodium fluoride varnish in arresting early childhood caries in preschool children: study protocol for a randomised controlled trial
The application of 38 % silver diamine fluoride (SDF) has been shown to be effective in arresting early childhood caries (ECC). Since SDF is not available in certain countries, some dentists use adjunctive app...
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Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway
This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is i...
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Open AccessImpact of routine coronary catheterization in low extremity artery disease undergoing percutaneous transluminal angioplasty: study protocol for a multi-center randomized controlled trial
The prevalence of significant obstructive coronary artery disease with complex lesions is high in patients who have low extremity artery disease (LEAD). However, intermediate- or long-term cardiovascular progn...