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Multi-Omics Approaches to Discovering Acute Stroke Injury and Recovery Mechanisms
Millions of people suffer an acute stroke each year, resulting in an enormous global burden of residual disability and mortality. Despite decades of...
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Identification of Host Factors of Paramyxoviruses by siRNA Genome-Wide Screens
Measles is a highly infectious disease that continues to spread mainly in develo** countries, often resulting in child mortality. Despite the...
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Culturing Immortalized Human Airway Epithelial Cells at an Air-Liquid Interface for Measles Virus Infection
Measles virus (MeV) infection of airway surface epithelial cells provides a site for final amplification before being released back into the...
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Proximity Ligation Assay to Detect the Proximity Between Host Proteins and Viral Proteins of HIV-1
The study of host-pathogen interaction often requires interrogating the protein-protein interactions and examining post-translational modifications...
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Molecular Analysis of Copy-Back Defective Interfering RNAs of Morbilliviruses
Copy-back defective interfering RNAs are major contaminants of viral stock preparations of morbilliviruses and other negative strand RNA viruses....
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Generation of Anti-HIV CAR-T Cells for Preclinical Research
The inability of people living with HIV (PLWH) to eradicate human immunodeficiency virus (HIV) infection is due in part to the inadequate...
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Design and Execution of In Vitro Polymerase Assays for Measles Virus and Related Mononegaviruses
Morbilliviruses such as measles virus (MeV) are responsible for major morbidity and mortality worldwide, despite the availability of an effective...
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Single-Virion Analysis: A Method to Visualize HIV-1 Particle Content Using Fluorescence Microscopy
HIV-1 virions incorporate viral RNA, cellular RNAs, and proteins during the assembly process. Some of these components, such as the viral RNA genome...
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Measles IgG Avidity Assay
Measles IgG avidity assays determine the overall strength of molecular binding between measles-specific IgG antibodies and measles virus antigens....
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Histopathological Analysis of Brains from Dogs Infected with Canine Distemper Virus
We describe the use of conventional histology and immunohistochemistry against canine distemper virus (CDV) to examine the brains of domestic dogs...
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Smith-Kingsmore Syndrome (SKS)
Gene defect: mTOR gene
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Popliteal Pterygium Syndrome
The first scientific reports of this syndrome date back to the latter part of the nineteenth century in cases described by Trelat (1869) and Wolff...
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Berlin Ectodermal Dysplasia Syndrome
Ectodermal dysplasia, Berlin type, is a rare congenital disorder consisting of generalized melanoleukoderma, hypodontia, hypotrichosis, infantilism,...
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Potocki-Lupski Syndrome
Potocki-Lupski syndrome (PTLS) is a rare neurodevelopmental disorder that occurs by heterozygous de novo microduplication in the short arm of...
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Mitochondrial Complex IV Deficiency, Nuclear (MC4DN) Types 1–24
Mitochondrial illnesses are a broad, diverse group of molecular disorders affecting the mitochondrial electron transport chain. Mitochondrial complex...
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Interstitial Lung Disease, Nephrotic Syndrome, and Epidermolysis Bullosa (ILNEB)
ILNEB is an extremely rare disease caused by mutations in the ITGA3 gene, which encodes the integrin α3 subunit of the major adhesion...
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Gonadal Dysgenesis, Dysmorphic Facies, Retinal Dystrophy, and Myopathy (GDRM)
Myo-Ectoderma-Gonadal Dysgenesis (MEGD) Syndrome.
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Immune Homeostasis Maintenance Through Advanced Immune Therapeutics to Target Atherosclerosis
Atherosclerosis remains the leading cause of coronary heart disease (CHD) with enormous health and societal tolls. Traditional drug development...
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Modulation and Determination of the Status of Inflammasomes in Leishmania-Infected Macrophages
Leishmania, an intra-macrophage kinetoplastid parasite, modulates a vast array of defensive mechanisms of the host macrophages to create a...