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Mutation and Genetic Drift
The emergence of genetic variation in natural and simulated populations depends on the production of new variants. The engine of variant production...
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Adhesion of Living Cells: Mechanisms of Adhesion and Contact Models
All known biological organisms consist of cells. Contact probing of cells is one of the preferred methods of studying cells’ mechanical properties....
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Indentation Tests of Biological Materials: Theoretical Aspects
The term ‘biological material’ includes many meanings, and here it means materials that constitute living organisms. The variety of material parts of...
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Characterisation of an AFM Tip Bluntness Using Indentation of Soft Materials
Bluntness of tips of atomic force microscopy (AFM) probes may affect the precision of AFM measurements of surface topography and accuracy of AFM...
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Effect of Viscoelasticity in Sliding Contact of Layered Solids
Quasi-static 3-D contact problem for a rigid smooth slider and a two-layered half-space with rheological properties of a layer or a substrate is...
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Population Structure and Migration
We begin with a discussion of how population structure is commonly modeled, including island, step**-stone, and isolation-by-distance models. The...
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Meiotic Recombination
The main outcome of this chapter is to extend the forward simulation program FORTUNA to include crossing-over within a simulated sequence. We begin...
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Quantitative Traits
Quantitative traits are determined by variation at multiple polygenes and the environment. In this chapter, FORTUNA is modified to allow simulation...
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Computational Bioengineering
Computational Bioengineering deals with engineering a dynamic biological system towards enhanced production of a desired product. It covers the...
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Systems Biology
Systems biology is an emerging approach to understand the holistic biology focussing on individual components of a biological system and their...
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Diversity of the Cell
Diversity is a key concept in biology that involves the discovery and description of diverse life forms. Finding commonalities among diverse life...
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Modeling Feedback Regulations
As we learned the importance of feedback regulations for self-organization in the previous chapter, we now learn how to develop a quantitative model...
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Differential Equations to Describe Temporal Changes
As biological systems are dynamic, modeling temporal changes is the key in quantitative biology. Modeling of temporal changes refers to the...
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Development of the Cell over Time (Perspectives)
As discussed in the previous chapter, the self-organization of the architecture of the cell is full of mystery. Another unanswered question is how...
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Mechanics of the Cell
The mechanics of the cell is a typical subject in quantitative biology. It is also a critical topic in cell architectonics. The movement of...
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Introduction to Bioinformatics and Computational Biology
Bioinformatics and computational biology are interdisciplinary subjects requiring good understanding of both biological and physical sciences....
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Next-Generation Sequencing
The next-generation sequencing platforms can generate a large amount of high-throughput sequencing data in a short span of time. Reference-based...
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Agricultural Bioinformatics
Agricultural bioinformatics can play a very important role in improving crop productivity. The important areas of agricultural bioinformatics are...
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Clinical Bioinformatics
Clinical bioinformatics is a powerful discipline that covers the development of various computational models describing initiation and progression of...
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Molecular Evolution
Molecular evolution occurs in the genome in the form of substitutions, insertion/deletion, recombination and gene conversion. The principles of...