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Systems Biology: necessary developments and trends
At the end of this definition of Systems Biology through exampling, we discuss ambitions, goals, and challenges relating to this new discipline. We... -
Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy
The chemistry of nitrido complexes of technetium has played an important role in the search of new Tc-99m radiopharmaceuticals and in providing... -
Scientific and technical challenges for systems biology
Systems biology is an emergent discipline, yet can be rooted back almost a century when pioneering thoughts on system-oriented views were discussed.... -
Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to... -
From isolation to integration, a systems biology approach for building the Silicon Cell
In the last decade, the field now commonly referred to as systems biology has developed rapidly. With the sequencing of whole genomes and the... -
Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized... -
Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors
The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great... -
Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as... -
Metabolic flux analysis: A key methodology for systems biology of metabolism
Genome-wide analyses of mRNA, protein, or metabolite complements of biological systems produce unprecedented data sets. In contrast to such cellular... -
Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
In this chapter we wish to present a vision of systems biology as a discipline that generates new insight and knowledge with quantitative and... -
Mathematical modelling of the Wnt-pathway
A kinetic model of the Wnt-signal transduction pathway is presented which includes the main molecular components of this system. It is based on a set... -
Systems Biology: Did we know it all along?
It is often suggested that Systems Biology is nothing new, or that it is irrelevant. Its central paradigm, i.e. that much of biological function... -
Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications
This review presents a comprehensive overview of the most significant developments in the chemistry of technetium and rhenium complexes anchored by... -
Systems biology of the yeast cell cycle engine
One goal of systems biology is to obtain an integrated understanding of the physiological properties of cells from the detailed molecular machinery... -
A modular systems biology analysis of cell cycle entrance into S-phase
A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the... -
What is systems biology? From genes to function and back
The essence of the grand contributions of physiology and molecular biology to biology is discussed in relation to what may be needed to understand... -
Modeling the E. coli cell: The need for computing, cooperation, and consortia
Escherichia coli K-12 is an ideal test bed for pushing forward the limits of our ability to understand cellular systems through computational... -
No music without melody: How to understand biochemical systems by understanding their dynamics
The dynamics of the concentration of biochemical species is a systems property that arises through the interaction of metabolites and other... -
Radiolabeled Integrin αvβ3 Antagonists as Radiopharmaceuticals for Tumor Radiotherapy
Integrins are a family of proteins that facilitate cellular adhesion to and migration on the extracellular matrix proteins found in intercellular... -
6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules
99mTc-labeled small biomolecules are a class of receptor-based, target specific radiopharmaceuticals for the detection of various diseases, such as...