Search
Search Results
-
2. Definition of Life
The definition of life is a long-standing debate with no general scientific consensus to be expected any time soon. The underlying problem is that...
-
Immobilization of Oligonucleotides for Biochemical Sensing by Self-Assembled Monolayers: Thiol-Organic Bonding on Gold and Silanization on Silica Surfaces
The covalent immobilization of biomolecules on surfaces is of great interest for many medical and bioanalytical applications. Currently, there is...
-
Immobilization of Nucleic Acids Using Biotin-Strept(avidin) Systems
There are several advantages for using biotin-streptavidin/avidin (strept(avi-din)) systems to immobilize nucleic acids and other molecules. These...
-
Immobilization of DNA on Microarrays
Microarrays are new analytical devices that allow the parallel and simultaneous detection of thousands of target compounds. Microarrays, also...
-
Impedimetric Detection of DNA Hybridization: Towards Near-Patient DNA Diagnostics
Immobilization strategies for the attachment of nucleotide probes to both microarrays and microfabricated interdigitated electrodes differ to...
-
5. Building Blocks of Life
Life is based on complex chemistry yet only a few of all the available elements participate in most life-supporting reactions on Earth: carbon,...
-
4. Energy Sources and Life
An external energy source is a necessary condition for life, because living systems require a flow of energy to organize materials and maintain a low...
-
Biological Organometallic Chemistry of B12
Vitamin B12, the “antipernicious anemia factor” required for human and animal metabolism, was discovered in the late 1940s. B12-derivatives are...
-
Histone Ubiquitylation and the Regulation of Transcription
The small (76 amino acids) and highly conserved ubiquitin protein plays key roles in the physiology of eukaryotic cells. Protein ubiquitylation...
-
The Generation and Recognition of Histone Methylation
The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing,...
-
Histone Dynamics During Transcription: Exchange of H2A/H2B Dimers and H3/H4 Tetramers During Pol II Elongation
Chromatin within eukaryotic cell nuclei accommodates many complex activities that require at least partial disassembly and reassembly of...
-
Folding of newly synthesised proteins in the endoplasmic reticulum
The endoplasmic reticulum (ER) is a membranous compartment that can be found within any nucleated eukaryotic cell. Its job is to oversee the...
-
Medicinal Properties of Organometallic Compounds
Although organometallic compounds are ubiquitous in nature, synthetic organometallic compounds are generally considered to be toxic or...
-
Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
-
Structural features of fungal genomes
Eighteen fungal genomes have been sequenced to date from a variety of taxonomic groups, with fifteen Ascomycota, two Basidomycota and one...
-
Directed Synthesis of Biologically Interesting Heterocycles with Squaric Acid (3,4-Dihydroxy-3-cyclobutene-1,2-dione) Based Technology
A variety of methods for organic transformation starting from squaric acid have been developed in this decade. These are based on conversion of...
-
Sterol Endocytosis and Trafficking in Plant Cells
Structural sterols are integral components of biological membranes. They regulate membrane permeability and fluidity, and they influence the...
-
Microwave-Assisted Multicomponent Reactionsfor the Synthesis of Heterocycles
Multicomponent reactions offer convenient procedures for the introduction of many points of structural diversity into heterocyclic compounds...
-
Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action
Diazonium salts have been previously used to cleave DNA via generation of carbon centered radicals and cations. Efforts have been made in the...
-
Quinazoline Alkaloids and Related Chemistry
Recent progress in quinazoline alkaloids and related chemistry was reviewed focusing on developments of the synthetic methodologies and their...