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State of the Art. Chemical Synthesis of Biophosphates and their Analogues via PIII Derivatives
This chapter is concerned with preparation and applications of tricoordinate phosphorus compounds in synthesis of biophosphates and their structural...
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Complexes with a Metal-Phosphorus Triple Bond
A survey of the existing complexes containing a transition metal-phosphorus triple bond is presented. Based on the different types of these...
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Molecular Components of Physiological Stress Responses in Escherichia coli
In order to survive under and adapt to different conditions Escherichia coli has evolved elaborate systems that are able to sense and respond to...
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DNA Electron Transfer Processes: Some Theoretical Notions
Charge motion within DNA stacks, probed by measurements of electric conductivity and by time-resolved and steady-state damage yield measurements, is...
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Polarons and Transport in DNA
It has been widely considered that the wavefunction of an extra electron or hole on the base stack of a DNA molecule is confined to a single site,...
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A Covalent Chemistry Approach to Giant Macromolecules with Cylindrical Shape and an Engineerable Interior and Surface
This article divides the synthetic routes leading to dendronized polymers into two main categories (attach-to and macromonomer) and compares their...
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Regeneration of Articular Cartilage
Loss of articular cartilage from the ends of bones forming diarthrodial joints can be the source of profound pain and disability, and eventually lead...
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Between Objectivity and Whim: Nucleic Acid Structural Biology
Here we explore the subjectivity intrinsic to macromolecular crystallography, focusing on the hydration/counter-ion region of nucleic acids. Water...
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Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to...
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Higher Harmonic Generation Microscopy
Higher harmonic-generation, including second harmonic generation and third harmonic generation, leaves no energy deposition to the interacted matters...
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Tracking Movement in Cell Biology
This article is an overview of techniques for measuring movement of proteins, vesicles and cells using digital image processing. Diverse techniques...
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Conserved ribosomal RNA modification and their putative roles in ribosome biogenesis and translation
rRNA maturation requires extensive covalent modifications of riboses and bases. These modifications concern exclusively the most conserved regions of...
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Biosynthesis and function of 1-methyladenosine in transfer RNA
Determining the function of single nucleotide modifications in tRNA has been elusive because so many tRNA modification enzymes are not essential for...
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From isolation to integration, a systems biology approach for building the Silicon Cell
In the last decade, the field now commonly referred to as systems biology has developed rapidly. With the sequencing of whole genomes and the...
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Adenosine to inosine RNA editing in animal cells
Major advances in the understanding of adenosine deaminases acting on RNA (ADARs) have come from the generation of ADAR mutant animals. In mice,...
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Beads Arraying and Beads Used in DNA Chips
The present article draws a general picture of the bead assisted DNA immobilization on chips. The authors wish to present these systems since...
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Phosphinidenes
Of the low-valent organophosphorus compounds phosphinidenes occupy a special place. In ‘free’ phosphinidenes the phosphorus atom carries a single...
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Electrochemical Adsorption Technique for Immobilization of Single-Stranded Oligonucleotides onto Carbon Screen-Printed Electrodes
The data reported in literature demonstrate that screen-printed carbon electrodes are very suitable for supporting nucleic-acid layers and to...
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Metabolic Engineering
Metabolic engineering is a powerful methodology aimed at intelligently designing new biological pathways, systems, and ultimately phenotypes...
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Scanning Probe Microscopy Studies of Surface-Immobilised DNA/Oligonucleotide Molecules
Although most in vivo biomolecular recognition occurs in solution, in many practical situations (e.g., diagnostics, drug discovery and biosensing)...