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  1. Immunotherapy for Gastrointestinal Malignancies

    Gastrointestinal (GI) malignancies comprise esophageal, stomach, liver, biliary tract, pancreatic, small bowel, appendiceal, colorectal, and anal...
    Chapter 2024
  2. Immunotherapies for Cancer: Bi-specific T Cell Engagers (BiTEs)

    Bi-specific T cell engagers (BiTEs) are immunologically active molecules with dual specificity, concurrently binding to a tumor-associated antigen...
    Richard C. Godby, Alex Niu, Jonas Paludo in The Basics of Cancer Immunotherapy
    Chapter 2024
  3. Melanoma Immunotherapy

    Melanoma is considered a highly immunogenic tumor due to its high level of somatic mutations and frequent expression of type I interferons. As such,...
    Erica L. Andres, Matthew S. Block in The Basics of Cancer Immunotherapy
    Chapter 2024
  4. Immune Checkpoint Inhibitors in Oncology

    In this chapter, we explore the evolution and current state of immune checkpoint inhibitors (ICIs) in cancer treatment, focusing on their mechanism...
    Katherine Smith, Svetomir N. Markovic in The Basics of Cancer Immunotherapy
    Chapter 2024
  5. Cellular Therapies for Cancer: Chimeric Antigen Receptor T Cells (CAR-T)

    Chimeric antigen receptor T cell (CAR-T), a novel modality of adoptive cellular therapy, is characterized by the expression of chimeric antigen...
    Richard C. Godby, Alex Niu, Jonas Paludo in The Basics of Cancer Immunotherapy
    Chapter 2024
  6. Chemoimmunotherapy Combination for Solid Tumors

    Novel cancer immunotherapies targeting the immunosuppressive PD-1/PD-L1 pathway result in durable clinical benefit in a subset of patients; however,...
    Chapter 2024
  7. Viral Immunotherapy Strategies in Clinical Practice

    Viruses are a tool that can be used to help activate the immune system against cancer. Viral genetics may be changed to make a virus less infectious...
    Jeffrey Johnson, James Jakub in The Basics of Cancer Immunotherapy
    Chapter 2024
  8. Pädiatrische Krebserkrankungen

    Obwohl Krebserkrankungen bei Kindern und Jugendlichen insgesamt selten sind, treten einige Krebsarten überwiegend bei Kindern und Jugendlichen auf....
    Chapter 2024
  9. Magenkrebs

    Magenkrebs bleibt weltweit eine häufige Ursache für Krebstodesfälle, doch seine Inzidenz ist in den meisten Ländern seit mehreren Jahrzehnten stark...
    Chapter 2024
  10. Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis

    Azithromycin was introduced in lung transplantation in an attempt to improve the pulmonary function in patients with chronic allograft dysfunction...
    Geert M. Verleden, Stijn E. Verleden in Macrolides as Immunomodulatory Agents
    Chapter 2024
  11. Non-CF Bronchiectasis

    Bronchiectasis is a disease of recurrent wet cough and acute respiratory exacerbations with objective confirmation by abnormal bronchial dilatation...
    Dustin Mills, Anne B. Chang, Julie M. Marchant in Macrolides as Immunomodulatory Agents
    Chapter 2024
  12. Macrolides and Asthma Therapy

    Asthma is a chronic condition of the airways that is typified by bronchial hyperresponsiveness, variable airflow obstruction, and airway...
    Krishna Undela, Adil Adatia, ... Giovanni Ferrara in Macrolides as Immunomodulatory Agents
    Chapter 2024
  13. Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity

    In addition to the antiinflammatory/immunoregulatory actions of macrolide antibiotics, more recent investigations indicate the potential...
    Clive P. Page, Fridrik R. Gardarsson, ... Michael J. Parnham in Macrolides as Immunomodulatory Agents
    Chapter 2024
  14. Macrolides and Cystic Fibrosis

    Macrolide antibiotics attracted interest as a potential therapy in cystic fibrosis (CF) due to remarkable similarities in pathogenic features with...
    Rishi Pabary, Adam Jaffe, Andrew Bush in Macrolides as Immunomodulatory Agents
    Chapter 2024
  15. Macrolides in Chronic Skin Disorders

    Macrolide antibiotics are widely used to treat infections of soft tissues and the respiratory tract due to their efficacy against Gram-negative and...
    Chapter 2024
  16. Leberkrebs

    Leberkrebs ist weltweit eine der tödlichsten Krebsarten. Dieses Kapitel beschreibt die molekulare Pathogenese des wichtigsten histologischen Subtyps,...
    Chapter 2024
  17. Darmkrebs

    Karzinome des Dick- und Enddarms (KolorektalKarzinome, CRC) gehören weltweit zu den am häufigsten auftretenden Krebsarten. Kolorektalkarzinome...
    Chapter 2024
  18. Krebsprävention

    Krebspräventionsmaßnahmen können als primär, sekundär oder tertiär eingestuft werden. Die Prävention kann sich an ganze Populationen, an...
    Chapter 2024
  19. Brustkrebs

    Brustkrebs (Mammakarzinom) ist eine der Haupttodesursachen bei Frauen, vergleichbar mit Lungen- und Darmkrebs. Ein Thema in diesem Kapitel sind die...
    Chapter 2024
  20. Krebsepigenetik

    Epigenetische Mechanismen etablieren zellspezifische Genexpressionsmuster, die stabil über Zellteilungen hinweg übertragen werden. Epigenetische...
    Chapter 2024
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