Search
Search Results
-
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine
Coordination complexes of cobalt represent a potential alternative to anticancer platinum-derived drugs owing to multiple activities and better...
-
Carboxymethylcellulose stabilized ZnO nanoparticles: an efficient nano-nutrient for the growth and development of Trigonella foenum-graecum (fenugreek) seeds
In the present study, carboxymethyl cellulose-capped ZnO nanoparticles (CMC@ZnO NPs) have been synthesized using the co-precipitation method where...
-
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
BackgroundSeveral countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics...
-
Herbidomicins, two pairs of polyketide tautomers produced by an actinomycete of the genus Herbidospora
Herbidospora is one of the underexplored actinomycete genera from which only a limited number of secondary metabolites are reported. In our...
-
Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) remains a major global health threat, claiming millions of lives annually. Despite recent advancements in managing...
-
Identification of potential natural product derivatives as CK2 inhibitors based on GA-MLR QSAR modeling, synthesis and biological evaluation
Protein kinase CK2 is a validated target for cancer therapy. Many natural products have shown inhibitory activity against CK2 as potential...
-
Targeting ROS in cancer: rationale and strategies
Reactive oxygen species (ROS) in biological systems are transient but essential molecules that are generated and eliminated by a complex set of...
-
Facile and cost-effective optical sensing of abamectin and ivermectin using gold nanoparticles conjugated with organosilicon compound and on cellulose filter paper
This study presents a novel, facile, and low-cost method for the separation and sensing of two closely related antiparasitic drugs, abamectin (ABM)...
-
Investigating the effect of cerium oxide nanoparticle on beta-amyloid-induced memory loss
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the loss of nerve cells in the hippocampus region of the brain, leading to...
-
Synthesis and anti-leishmanial activities of uniflorol analogues
Chromanones are a subset of the benzopyran family, and display diverse biological activities, both as natural products and synthetic derivatives....
-
The cyclization and functionalization reactions involving N-phenacylpyridinium salts
Pyridinium salts have been used as starting materials and intermediates in 1,3-dipolar cycloaddition with dipolarophiles. Among them, N -phenacylpyridi...
-
Synthesis, antimicrobial evaluation, and molecular docking studies of Mannich base analogs derived from 2,3-dihydro-1,3,4-oxadiazole-2(3H)-thione scaffold
A series of novel trans-3-substituted aminomethyl-5-(4-(4-chlorophenyl)cyclohexyl)-1,3,4-oxadiazole-2(3 H )-thiones was synthesized successfully from...
-
Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model
Substituted furan carboxamide and Schiff base derivatives were evaluated for their hypolipidemic activity. Fourteen derivatives were synthesised:...
-
Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications
Because of CO’s known endogenous signaling roles and its demonstrated pharmacological activity at low and safe concentrations, there is considerable...
-
Comparative study of physical properties of hydroxyapatite derived from Asian moon scallop and batik shells using sol–gel techniques for producing inorganic membrane plate
Approximately 33% of organic waste generated in Indonesia is food waste. The waste such as animal bones, seashells, and eggshells with CaCO 3 are...
-
Eclipsed conformational locking: exploring iota carrageenan’s distinct behavior in ethanol–water systems via hydrogen bonding with the disulfate group
The present investigation combines diverse experimental methodologies with meticulous examination of the alterations throughout the technique and...
-
Repurposing of Drug Bank Compounds against Plasmodium falciparum Dihydroorotate Dehydrogenase as novel anti malarial drug candidates by Computational approaches
This study aimed to repurpose Drug Bank Compounds against P. falciparum Dihydroorotate dehydrogenase (Pf-DHODH)a potential molecular target for...
-
Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
-
Unraveling metabolic pathways and key genes in Alzheimer’s, type 2 diabetes, and estrogen dysregulation among aging women: a systems biology approach
BackgroundAlzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) present significant global health challenges, particularly affecting aging...
