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Identification of HOXC Gene Family as Prognostic and Immune-Related Biomarkers in Breast Cancer Through mRNA Transcriptional Profile and Experimental Validation
Breast cancer (BC) is the most common malignancy in women worldwide, and more effective biomarkers are urgently needed for the prevention and...
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Priming antibody responses to the fusion peptide in rhesus macaques
Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required...
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Selective depletion of Campylobacter jejuni via T6SS dependent functionality: an approach for improving chickens gut health
The targeted depletion of potential gut pathogens is often challenging because of their intrinsic ability to thrive in harsh gut environments....
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Temporal change in the parasite community of an invasive fish Trachelyopterus galeatus (Siluriformes: Auchenipteridae) in a neotropical floodplain
The construction of dams and hydroelectric plants affects biodiversity in aquatic environments and can facilitate the invasion of species. Few...
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Understanding the impact of COVID-19 on antibiotic use in Canadian primary care: a matched-cohort study using EMR data
BackgroundInappropriate or overuse of antibiotic prescribing in primary care highlights an opportunity for antimicrobial stewardship (AMS) programs...
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Gastric bezoars secondary to mixed infection with Sarcina ventriculi and G + bacilli: a case report
Sarcina ventriculi is a bacterium with a specific histological morphology and infection can present with symptoms such as abdominal pain, nausea,...
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Analyzing the molecular mechanism of Scutellaria Radix in the treatment of sepsis using RNA sequencing
BackgroundSepsis is a life-threatening organ dysfunction, which seriously threatens human health. The clinical and experimental results have...
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Multicenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment
BackgroundInfections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of...
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Biliary atresia
Biliary atresia (BA) is a progressive inflammatory fibrosclerosing disease of the biliary system and a major cause of neonatal cholestasis. It...
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Staphylococcus aureus screening and preoperative decolonisation with Mupirocin and Chlorhexidine to reduce the risk of surgical site infections in orthopaedic surgery: a pre-post study
BackgroundNasal carriage of Staphylococcus aureus is a risk factor for surgical site infections (SSI) in orthopaedic surgery. The efficacy of...
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Development and validation of extraction and clean-up procedures for UPLC-MS/MS analysis of aflatoxins in spices
UPLC-MS/MS analytical conditions for the analysis of aflatoxins in spices were optimized and validated in this study. Liquid-liquid partition-based...
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Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the...
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Antimicrobial efficacy and amino acid substitutions associated with susceptibility to the tellurium compound AS101 against Haemophilus influenzae and Haemophilus parainfluenzae
The tellurite toxicity in Haemophilus influenzae and H. parainfluenzae remains unclear. To understand the potential of tellurite as a therapeutic...
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An adult with hemorrhagic varicella co-infects with cytomegalovirus: a case report
BackgroundHemorrhagic varicella (HV) is a particular form of chicken pox.,with high mortality in adults. This form of the disease is rare, to date,...
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Comparative analysis of two novel complete genomes of myxoma virus vaccine strains
Myxoma virus (MYXV) is a double-stranded DNA-containing virus of the family Poxviridae , genus Leporipoxvirus . MYXV is an important model virus for...
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Inconsistency of in vitro exsheathment triggers for gastrointestinal nematode parasites of sheep, cattle and deer
Exsheathment is crucial in the transition from free-living to parasitic phase for most strongyle nematode species. A greater understanding of this...
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Individual and combined occurrences of the prevalent mycotoxins in commercial feline and canine food
Mycotoxins, such as aflatoxin B 1 (AFB 1 ), deoxynivalenol (DON), fumonisins (FBs), ochratoxin A (OTA), T-2 toxin (T-2), and zearalenone (ZEN), can...
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miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4
Upregulation of ADAMTS-4 has been reported to have an important role in lung injury, and ADAMTS-4 expression is regulated by miR-126a-5p in abdominal...
