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DNN-BP: a novel framework for cuffless blood pressure measurement from optimal PPG features using deep learning model
AbstractContinuous blood pressure (BP) provides essential information for monitoring one’s health condition. However, BP is currently monitored using...
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Basal release of 6-cyanodopamine from rat isolated vas deferens and its role on the tissue contractility
6-Cyanodopamine is a novel catecholamine released from rabbit isolated heart. However, it is not known whether this catecholamine presents any...
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The ATP-Binding Cassette Transporter-Mediated Efflux Transport of Ganciclovir at the Blood–Brain Barrier
Background and ObjectiveRecent studies have highlighted the key role of the ATP-binding cassette (ABC) transporters, including the P-glycoprotein...
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Impact of rest interval duration on post-exercise recovery dynamics, ventilatory threshold and respiratory compensation point in endurance athletes: A randomized controlled trial
ObjectiveThe primary objective of this study was to investigate the impact of varying rest interval durations in High-Intensity Interval Training...
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Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus , and Lachesis ....
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Can photoperiod improve growth performance and antioxidant responses of pacu (Piaractus mesopotamicus) reared in recirculation aquaculture systems?
The present study investigated the best photoperiod for culturing pacu ( Piaractus mesopotamicus ) in recirculation aquaculture systems (RAS) based on...
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The Competitive Counterflow Assay for Identifying Drugs Transported by Solute Carriers: Principle, Applications, Challenges/Limits, and Perspectives
The identification of substrates for solute carriers (SLCs) handling drugs is an important challenge, owing to the major implication of these plasma...
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Validation of the Charlson Comorbidity Index for the prediction of 30-day and 1-year mortality among patients who underwent hip fracture surgery
IntroductionThe aim of our study was to validate the original Charlson Comorbidity Index (1987) (CCI) and adjusted CCI (2011) as a prediction model...
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Racial differences in serological markers across the first year of injury in spinal cord injury: a retrospective analysis of a multi-center interventional study
Study designSecondary analysis of a randomized, multi-center, placebo-controlled study(Sygen®).
ObjectivesTo evaluate racial differences in...
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Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model
PurposeGrowth hormone (GH) is a central regulator of β-cell proliferation, insulin secretion and sensitivity. Aim of this study was to investigate...
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Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features
PurposeCardiopulmonary exercise testing (CPET) is considered the gold standard for assessing cardiorespiratory fitness. To ensure consistent...
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Revisiting reactive oxygen species production in hypoxia
Cellular responses to hypoxia are crucial in various physiological and pathophysiological contexts and have thus been extensively studied. This has...
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Predictive modeling of perioperative patient deterioration: combining unanticipated ICU admissions and mortality for improved risk prediction
ObjectiveThis paper presents a comprehensive analysis of perioperative patient deterioration by develo** predictive models that evaluate...
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The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
Aims/hypothesisStrategies to augment functional beta cell mass include directed differentiation of stem cells towards a beta cell fate, which...
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Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively targeting ectonucleotidases, are essential in altering...
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Differences in the pupillary responses to evening light between children and adolescents
BackgroundIn the mammalian retina, intrinsically-photosensitive retinal ganglion cells (ipRGC) detect light and integrate signals from rods and cones...
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Experience of exercising in a noisy environment disrupts hippocampal biochemical responses to light intensity exercise
PurposeThe hippocampus is a brain region susceptible to the deleterious effects of stressors. Therefore, it is crucial to comprehend the adverse...
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Transgender healthcare: metabolic outcomes and cardiovascular risk
Transgender identity is often associated with gender dysphoria and minority stress. Gender-affirming hormone treatment (GAHT) includes masculinising...
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Frequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernators
Hibernation allows mammals to endure harsh seasons by reducing their basal metabolism and body temperature (Tb) to minimize energy expenditure....
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Static and temporal dynamic alterations of regional homogeneity in chronic insomnia: a resting-state fMRI study
To explore brain function alterations in chronic insomnia (CI). 65 CI patients and 48 healthy controls were included to analyze abnormal alterations...
