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A rare partnership: patient community and industry collaboration to shape the impact of real-world evidence on the rare disease ecosystem
People with rare lysosomal storage diseases face challenges in their care that arise from disease complexity and heterogeneity, compounded by many...
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Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes
Age at diagnosis (AAD) of Type 1 diabetes (T1D) is determined by the age at onset of the autoimmune attack and by the rate of beta cell destruction...
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling...
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Implementation of remote general movement assessment using the in-motion instructions in a high-risk norwegian cohort
BackgroundGeneral Movement Assessment (GMA) is recommended for early detection of risk for cerebral palsy but requires trained clinical experts. We...
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Normalized lactate load as an independent prognostic indicator in patients with cardiogenic shock
BackgroundEarly prognosis evaluation is crucial for decision-making in cardiogenic shock (CS) patients. Dynamic lactate assessment, for example,...
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Comparison between head rotation and standard techniques for i-gel™ insertion: a randomized controlled trial
BackgroundThis study evaluated the effect of head rotation on the first-attempt success rate of i-gel insertion, aiming to alleviate the effect of...
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Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization
Early diagnosis of head and neck cancer can improve therapeutic outcomes but remains a challenge. The blood proteome can comprise a key source of...
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Bioactivity and antibacterial effect of star anise biosynthesized silver nanoparticles against Streptococcus mutans: an in vitro study
BackgroundSilver nanoparticles (AgNPs) are receiving a lot of attention as a prospective antibacterial agent for use in caries prevention. The...
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Apolipoprotein E E3/E4 genotype is associated with an increased risk of premature coronary artery disease
ObjectiveDyslipidemia is one of the causes of coronary heart disease (CAD), and apolipoprotein E (APOE) gene polymorphism affects lipid levels....
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Seagrass as a potential nutraceutical to decrease pro-inflammatory markers
BackgroundThe Pro-inflammatory mediators such as prostaglandin E2, nitric oxide and TNF-α are the key players in the stimulation of the inflammatory...
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Analysis of the impact of a university distance learning course on digitalization in medicine on students and healthcare professionals
PurposeThe public medical universities in Austria (educating 11,000 students) developed a joint public distance learning series in which clinicians...
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Differentiating between benign and malignant breast lesions using dual-energy CT-based model: development and validation
ObjectivesTo develop and validate a dual-energy CT (DECT)-based model for noninvasively differentiating between benign and malignant breast lesions...
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Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Aims/hypothesisAlterations in circadian rhythms increase the likelihood of develo** type 2 diabetes and CVD. Circadian rhythms are controlled by...
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Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study
Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for...
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“Textbook outcome(s)” in colorectal surgery: a systematic review and meta-analysis
BackgroundTextbook outcome (TO) is a composite measure used in surgery to evaluate post operative outcomes. No review has synthesised the evidence in...
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Effects of polygenic risk score and sodium and potassium intake on hypertension in Asians: A nationwide prospective cohort study
Genetic factors, lifestyle, and diet have been shown to play important roles in the development of hypertension. Increased salt intake is an...
