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Non-surgical vs. surgical treatment of distal radius fractures: a meta-analysis of randomized controlled trials
PurposeTo compare the clinical outcomes between nonsurgical and surgical treatment of distal radius fracture.
MethodsWe performed a systematic...
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Health-related quality of life and symptoms of chronic myeloid leukemia patients after discontinuation of tyrosine kinase inhibitors: results from the EURO-SKI Trial
Limited data is available on the health-related quality of life (HRQoL) and symptoms of patients with chronic myeloid leukemia (CML) who are in...
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Expanding the phenotypic spectrum of CC2D2A-related ciliopathies: a rare homozygous nonsense variant in a patient with suspected nephronophthisis
Biallelic pathogenic variants in the gene CC2D2A cause a spectrum of ciliopathies, including Joubert and Meckel syndrome, which frequently involve...
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Urine biomarkers in type 2 diabetes mellitus with or without microvascular complications
ObjectiveTo investigate the distribution of nine (9) urine biomarkers in people living with type 2 diabetes mellitus (T2DM), with or without...
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Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat
IntroductionThe current obesity crisis has resulted in many people with excess adipose tissue suffering from chronic inflammation. This inflammation...
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Obstetric cholestasis and its impact on the maternal outcome
AimTo evaluate the association of GDM and pre-eclampsia in women with obstetric cholestasis.
Materials and methodsPregnant women with > 28 weeks...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review
Purpose of ReviewIntervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause of lower back pain, which seriously...
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A retrospective analysis of treatment patterns, overall survival, and real-world disease-free survival in early-stage non-small cell lung cancer following complete resection
BackgroundReal-world data regarding patient characteristics, adjuvant treatment patterns, and long-term survival outcomes are needed to better...
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Psychosocial and biological pathways to aging
While the biological hallmarks of aging are widely recognized as fundamental mechanisms of biological aging, more recently, there have been calls...
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Patients with High Baseline Neutrophil-to-Lymphocyte Ratio Exhibit Better Response to Filgotinib as Treatment for Rheumatoid Arthritis
IntroductionHigh baseline neutrophil-to-lymphocyte ratio (NLR) in rheumatoid arthritis (RA) has been associated with positive responses to biologic...
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sciMET-cap: high-throughput single-cell methylation analysis with a reduced sequencing burden
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust,...
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TFscope: systematic analysis of the sequence features involved in the binding preferences of transcription factors
Characterizing the binding preferences of transcription factors (TFs) in different cell types and conditions is key to understand how they...
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A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults
Background/ObjectiveTo identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).
MethodsAdult Indigenous Americans...
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Predictive role of platelets to lymphocytes ratio and neutrophil to lymphocytes ratio in COPD exacerbation
BackgroundThe hallmark of COPD is the progressive destruction of the lung parenchyma, which is frequently brought on by the body's inflammatory...
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Safety of Rimegepant in Adults with Migraine and Cardiovascular Risk Factors: Analysis of a Multicenter, Long-Term, Open-Label Study
IntroductionCardiovascular (CV) risk factors can limit treatment options for migraine. Rimegepant is an orally administered small-molecule calcitonin...
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Pharmacogenetics in Italy: current landscape and future prospects
Pharmacogenetics investigates sequence of genes that affect drug response, enabling personalized medication. This approach reduces drug-induced...
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Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages
Liver X receptors (LXRs) which link lipid metabolism and inflammation, were overexpressed in experimental rheumatoid arthritis (RA) rats as observed...
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An unenhanced 3D-FLAIR sequence using long repetition time and constant flip angle to image endolymphatic hydrops
ObjectivesTo evaluate a three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) sequence using a long repetition time (TR) and constant flip...
