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Sequential therapy of refractory metastatic pancreatic cancer with 5-FU/LV/irinotecan (FOLFIRI) vs. 5-FU/LV/oxaliplatin (OFF). The PANTHEON trial (AIO PAK 0116)
PurposeIn patients with metastatic pancreatic cancer, after failure of gemcitabine/nab-paclitaxel, this trial compares the efficacy of second-line...
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Recurrence in isolated distal DVT after anticoagulation: a systematic review and meta-analysis of axial and muscular venous thrombosis
ObjectiveTo identify recurrent venous thromboembolism (VTE) after discontinuation of anticoagulation in patients with isolated distal deep vein...
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Metabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis
ObjectiveTo conduct a systematic review and meta-analysis of case–control and cohort human studies evaluating metabolite markers identified using...
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Complement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease
IgA nephropathy (IgAN) is still one of the leading causes of end-stage kidney disease (ESRD), and complement system activation is a key to the...
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The potential role of serum amyloid A as biomarker of rheumatic diseases: a systematic review and meta-analysis
The identification of novel, robust biomarkers for the diagnosis of rheumatic diseases (RDs) and the presence of active disease might facilitate...
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ISG15 promotes tumor progression via IL6/JAK2/STAT3 signaling pathway in ccRCC
Although renal cell carcinoma (RCC) is a prevalent type of cancer, the most common pathological subtype, clear cell renal cell carcinoma (ccRCC),...
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Cancer fatalism, social media informational awareness, and education
ObjectiveUnderstand if cancer fatalism among adult social media users in the United States is linked to social media informational awareness and if...
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Daily Versus Alternate Day Oral Iron Replacement for Women with Iron Deficiency Anaemia: A Randomized Controlled Trial
The optimal way of oral iron replacement for iron deficiency anaemia(IDA) is still unknown and few recent studies have reported better fractional...
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PD-L1 inhibitor versus PD-1 inhibitor plus bevacizumab with transvascular intervention in unresectable hepatocellular carcinoma
Both atezolizumab (a PD-L1 inhibitor) plus bevacizumab (A+B) and sintilimab (a PD-1 inhibitor) plus bevacizumab (S+B) are recommended as the...
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The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance
RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We...
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Update on kidney injury caused by multiple myeloma
Multiple myeloma (MM) is a form of clonal plasma cell malignancy that associates with clinical manifestations such as anemia, hypercalcemia, bone...
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Cancer metastasis through the lymphatic versus blood vessels
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the...
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Heparin-induced thrombocytopenia in extracorporeal membrane oxygenation-supported patients: a systematic review and meta-analysis
BackgroundIn recent years, extracorporeal membrane oxygenation (ECMO) has been increasingly used in critically ill patients with respiratory or...
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Association of elevated circulating monocyte-platelet aggregates with hypercoagulability in patients with nephrotic syndrome
BackgroundHypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation...
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Personalized therapy in oncology: melanoma as a paradigm for molecular-targeted treatment approaches
In recent decades, the field of systemic cancer treatment has seen remarkable changes due to advancements in the understanding of cancer’s biology,...
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Refractory pure red cell aplasia associated with T-cell large granular lymphocyte leukemia treated by ruxolitinib
Acquired pure red cell aplasia (PRCA) is a rare syndrome characterized by normocytic normochromic anemia with severe reticulocytopenia and absence of...
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Risk factors and long-term outcomes for human herpesvirus 6 encephalitis in the early period after allogeneic stem cell transplantation
Human herpesvirus 6 (HHV6) encephalitis is a rare but life-threatening complication for patients undergoing allogeneic hematopoietic stem cell...
