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Wearable cuffless blood pressure tracking: when will they be good enough?
Wearable health monitoring is a multibillion-dollar industry. But the holy grail is probably getting it right for blood pressure monitoring without a...
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An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
BackgroundTo explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
MethodsBased on TCGA and GTEx databases, we used TIMER2.0...
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Exosomes derived from human urine–derived stem cells ameliorate IL-1β-induced intervertebral disk degeneration
BackgroundHuman intervertebral disk degeneration (IVDD) is a sophisticated degenerative pathological process. A key cause of IVDD progression is...
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Preliminarily exploring the intraoperative ultrasonography characteristics of patients with degenerative cervical myelopathy
BackgroundHow to quickly read and interpret intraoperative ultrasound (IOUS) images of patients with degenerative cervical myelopathy (DCM) to obtain...
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Combined neurokinin-1 receptor antagonist and sorafenib is a promising approach for hepatocellular carcinoma therapy
BackgroundHCC (Hepatocellular carcinoma) is the most common primary malignant cancer in the liver. Treatment options to incurable HCC such as...
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Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma
BackgroundSarcomas are diverse neoplasms with highly variable histological appearances in which diagnosis is often challenging and management options...
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Temporal relationship between hepatic steatosis and fasting blood glucose elevation: a longitudinal analysis from China and UK
BackgroundThe link between nonalcoholic fatty liver disease and type 2 diabetes has not been fully established. We investigated the temporal...
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Comparison of FGM prevalence among Nigerian women aged 15–49 years using two household surveys conducted before and after the COVID-19 pandemic
BackgroundDue to its economic burden and change of focus, there is no gainsaying of the potential impacts of the COVID-19 pandemic on the progress of...
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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1)...
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An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score
Heart failure with preserved ejection fraction (HFpEF) is under-recognized in clinical practice. Although a previously developed risk score, termed H 2 ...
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Hippocampal network activity forecasts epileptic seizures
Seizures in people with epilepsy were long thought to occur at random, but recent methods for seizure forecasting enable estimation of the likelihood...
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Understanding the impact of COVID-19 on antibiotic use in Canadian primary care: a matched-cohort study using EMR data
BackgroundInappropriate or overuse of antibiotic prescribing in primary care highlights an opportunity for antimicrobial stewardship (AMS) programs...
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An 18-gene signature of recurrence-associated endothelial cells predicts tumor progression and castration resistance in prostate cancer
BackgroundThe prognostic and therapeutic implications of endothelial cells (ECs) heterogeneity in prostate cancer (PCa) are poorly understood.
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Extrachromosomal circular DNA promotes prostate cancer progression through the FAM84B/CDKN1B/MYC/WWP1 axis
BackgroundExtrachromosomal circular DNA (eccDNA), a kind of circular DNA that originates from chromosomes, carries complete gene information,...
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A Mixed Methods Investigation Examining the PrEP Cascade Among 13–18-Year-Old Latino Adolescent Sexual Minority Men
Latino adolescent sexual minority men (ASMM) are at high risk of HIV. Limited research has explored the impact of parent-adolescent communication and...
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Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers
BackgroundFusobacterium nucleatum inhabits the oral cavity and affects the progression of gastrointestinal cancer. Our prior findings link F....
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Blood pressure is associated with knee pain severity in middle-aged and elderly individuals with or at risks for osteoarthritis: data from the Osteoarthritis Initiative
BackgroundHypertension is a common comorbidity of osteoarthritis (OA). Joint pain is the main clinical manifestation of OA. Knowledge about the...
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Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration
AbstractFatty liver, which is induced by abnormal lipid metabolism, is one of the most common causes of chronic liver disease globally and causes...
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The relationship between the duration and the retraction and atrophy grades in traumatic isolated full-thickness supraspinatus tears in young patients
BackgroundThe study aimed to determine the grade of retraction and atrophy according to the time elapsed in traumatic isolated full-thickness...
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Prediction method of pharmacokinetic parameters of small molecule drugs based on GCN network model
ContextAccurately predicting plasma protein binding rate (PPBR) and oral bioavailability (OBA) helps to better reveal the absorption and distribution...
