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Association between negative life events and suicidal behavior in adolescents: roles of core self-evaluation, depression and gender
PurposeNegative life events are essential proximal factors that may induce suicidal behavior in adolescents, but the mechanisms connecting this link...
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The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis
BackgroundGastric cancer (GC) is a deadly disease with poor overall survival and limited therapeutic options. Genetic alterations such as mutations...
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Exploring the complexity of EEG patterns in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily associated with motor dysfunctions. By the time of definitive...
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Prevalence of interarm blood pressure difference is notably higher in women; the Viborg population-based screening program (VISP)
BackgroundBilateral blood pressure (BP) measurement is important in cardiovascular prevention for identifying systolic interarm BP difference (IAD)...
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Urban Scaling Functions: Emission, Pollution and Health
Urban scaling is widely used to characterize the population dependence of city indicators including greenhouse gas emission. Here we analyze the...
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“Older people will die of old age. I’ll die of climate change”: engaging children and young people in climate decision making for public health
BackgroundThe climate crisis is a significant risk to the health and wellbeing of children, young people, and future generations. While there are...
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Peptides and Wound Healing: From Monomer to Combination
Peptides are a kind of compounds formed by α-amino acids linked together by peptide bonds, which are also intermediate products of protein...
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Challenges in the Transition from Acute Hospital Care to Home for Spanish-Speaking Latino Patients with TBI and Families: Perspectives of Healthcare Providers and Interpreters
Language-based disparities negatively impact patient outcomes. Spanish-speaking Latino patients with traumatic brain injury (TBI) transitioning home...
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Physical activity is associated with lower mortality in adults with obesity: a systematic review with meta-analysis
BackgroundObesity is a complex chronic disease associated with several adverse health outcomes that increase mortality risk. Physical activity (PA)...
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The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
BackgroundMultiple sclerosis (MS) therapeutic goals have traditionally been dichotomized into two distinct avenues: immune-modulatory-centric...
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RNA editing regulates glutamatergic synapses in the frontal cortex of a molecular subtype of Amyotrophic Lateral Sclerosis
BackgroundAmyotrophic Lateral Sclerosis (ALS) is a highly heterogenous neurodegenerative disorder that primarily affects upper and lower motor...
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BRD7 facilitates ferroptosis via modulating clusterin promoter hypermethylation and suppressing AMPK signaling in diabetes-induced testicular damage
BackgroundDiabetes mellitus (DM)-induced testicular damage is associated with sexual dysfunction and male infertility in DM patients. However, the...
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Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation
The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to...
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Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration
The senescence of nucleus pulposus (NP) cells (NPCs), which is induced by the anomalous accumulation of reactive oxygen species (ROS), is a major...
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Mesomelia-synostoses syndrome: contiguous deletion syndrome, SULF1 haploinsufficiency or enhancer adoption?
BackgroundMesomelia-Synostoses Syndrome (MSS)(OMIM 600,383) is a rare autosomal dominant disorder characterized by mesomelic limb shortening, acral...
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Changes in femoral anteversion after intramedullary nailing for pediatric femoral shaft fracture: a multicenter study
BackgroundThe rotational change after using a flexible intramedullary (IM) nail for femoral shaft fractures has been a concern for many surgeons....
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Macrophage membrane-reversibly camouflaged nanotherapeutics accelerate fracture healing by fostering MSCs recruitment and osteogenic differentiation
The fracture healing outcome is largely dependent on the quantities as well as osteogenic differentiation capacities of mesenchymal stem cells (MSCs)...
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Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder
Recent advances in surgical neuromodulation have enabled chronic and continuous intracranial monitoring during everyday life. We used this...
