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Momelotinib versus Continued Ruxolitinib or Best Available Therapy in JAK Inhibitor-Experienced Patients with Myelofibrosis and Anemia: Subgroup Analysis of SIMPLIFY-2
IntroductionSome Janus kinase (JAK) inhibitors such as ruxolitinib and fedratinib do not address and may worsen anemia in patients with...
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Do-not-attempt-resuscitation decision making: physicians’ recommendations differ from the GO-FAR score predictions
Background and aimIn-hospital cardiac arrest (IHCA) is a major cause of mortality globally, and over 50% of the survivors will require institutional...
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Bicuspid Aortic Valve Function and Aortopathy on Presentation and Progression in Children: Does Sex Difference Have Any Implications?
Bicuspid aortic valve (BAV) is the most common congenital heart defect. It can be accompanied by aortic regurgitation or stenosis with aortopathies....
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Consequences of ionizing radiation exposure to the cardiovascular system
Ionizing radiation is widely used in various industrial and medical applications, resulting in increased exposure for certain populations. Lessons...
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Urine biomarkers in type 2 diabetes mellitus with or without microvascular complications
ObjectiveTo investigate the distribution of nine (9) urine biomarkers in people living with type 2 diabetes mellitus (T2DM), with or without...
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Adaptation of risk prediction equations for cardiovascular outcomes among patients with type 2 diabetes in real-world settings: a cross-institutional study using common data model approach
ObjectiveTo adapt risk prediction equations for myocardial infarction (MI), stroke, and heart failure (HF) among patients with type 2 diabetes in...
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Predictors of ventricular tachyarrhythmia in patients with a wearable cardioverter defibrillator: an international multicenter registry
Background and aimsWearable cardioverter defibrillator (WCD) can protect patients from sudden cardiac death due to ventricular tachyarrhythmias and...
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Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Diabetic cardiomyopathy (DCM) is a chronic disease caused by diabetes mellitus, which is recognized as a worldwide challenging disease. This study...
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Interplay of the heart, spleen, and bone marrow in heart failure: the role of splenic extramedullary hematopoiesis
Improvements in therapies for heart failure with preserved ejection fraction (HFpEF) are crucial for improving patient outcomes and quality of life....
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Effect of direct oral anticoagulant therapy on pulmonary artery clot dissolution in intermediate high-risk pulmonary thromboembolism
BackgroundDirect oral anticoagulants are the established drugs for treating pulmonary thromboembolism. The advantage of direct oral anticoagulants...
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Nexilin in cardiomyopathy: unveiling its diverse roles with special focus on endocardial fibroelastosis
Cardiac disorders exhibit considerable heterogeneity, and understanding their genetic foundations is crucial for their diagnosis and treatment....
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A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults
Background/ObjectiveTo identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).
MethodsAdult Indigenous Americans...
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Contraceptive counselling and uptake of contraception among women with cardiovascular diseases: a systematic review and meta-analysis
To address the lack of clarity regarding contraceptive counselling and uptake of contraception among women with cardiovascular disease (CVD), this...
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Diacerein mitigates endocrine and cardio-metabolic disruptions in experimental PCOS mice model by modulating AdipoR1/ PON 1
BackgroundThis study aimed to explore the impact of Diacerein (DIC) on endocrine and cardio-metabolic changes in polycystic ovarian syndrome (PCOS)...
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Normalized lactate load as an independent prognostic indicator in patients with cardiogenic shock
BackgroundEarly prognosis evaluation is crucial for decision-making in cardiogenic shock (CS) patients. Dynamic lactate assessment, for example,...
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Pathogenesis of cardiovascular diseases: effects of mitochondrial CF6 on endothelial cell function
Cardiovascular disease (CVD) stands as a predominant global cause of morbidity and mortality, necessitating effective and cost-efficient therapies...
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Acetazolamide therapy in patients with acute heart failure: a systematic review and meta-analysis of randomized controlled trials
Acute heart failure (AHF) often leads to unfavorable outcomes due to fluid overload. While diuretics are the cornerstone treatment, acetazolamide may...
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Unraveling the Complex Relationship—Atrial Fibrillation and Pulmonary Hypertension
Purpose of ReviewIn this article, we underscore the importance of identifying risk factors and monitoring pulmonary hypertension patients for signs...
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Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism
Astrocytes are the most numerous type of glial cells found in the nervous system. They regulate energy homeostasis in collaboration with the neuronal...
