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  1. Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia

    Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by an isolated decrease in platelets below 100 × 10 9 /l after...

    Asmaa M. Zahran, Omnia H. El-Badawy, ... Khalid I. Elsayh in Clinical and Experimental Medicine
    Article Open access 15 July 2024

  2. Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice

    Purpose

    Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain...

    Marco F. Taddio, Suraj Doshi, ... Christine E. Mona in European Journal of Nuclear Medicine and Molecular Imaging
    Article Open access 15 July 2024

  3. Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses

    Background

    Nivolumab monotherapy is the standard second-line treatment for advanced esophageal squamous cell carcinoma (ESCC) after failure of...

    Yuko Murashima, Shun Yamamoto, ... Ken Kato in Journal of Gastrointestinal Cancer
    Article Open access 15 July 2024

  5. Targeting oncogene-induced cellular plasticity for tumor therapy

    Cellular plasticity, the remarkable adaptability of cancer cells to survive under various stress conditions, is a fundamental hallmark that...

    Bin Li, Lingling Zheng, ... Lianghu Qu in Advanced Biotechnology
    Article Open access 15 July 2024

  6. DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2

    DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...

    Yanxia Liu, Sandra Theil, ... Jochen Walter in Cellular and Molecular Life Sciences
    Article Open access 15 July 2024

  7. TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers

    Background

    Detection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...

    Dalin **ong, Tiancheng Han, ... Chunguang Li in BMC Cancer
    Article Open access 15 July 2024

  8. SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

    Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their...

    Can Chen, Yun Li, ... Shenxian Qian in Apoptosis
    Article Open access 15 July 2024

  9. Interrelationship between thyroid hormones and reduced renal function, a review article

    Background

    Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications...

    Sadaf Agahi, Atieh Amouzegar, ... Ladan Mehran in Thyroid Research
    Article Open access 15 July 2024

  10. SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

    A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...

    Ziming Li, Zhengbo Song, ... Shun Lu in Signal Transduction and Targeted Therapy
    Article Open access 15 July 2024

  11. Map** alternative splicing events in colorectal cancer

    Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...

    Yifeng Zheng, Guoqiang Zhong, ... Mingsong Li in Discover Oncology
    Article Open access 15 July 2024

  13. Embelin Mitigates Amyloid-β-Induced Neurotoxicity and Cognitive Impairment in Rats: Potential Therapeutic Implications for Alzheimer’s Disease

    Alzheimer’s disease (AD) is a significant form of dementia. Embelin (EMB) is a natural compound with varied actions that could help prevent AD...

    Rimpi Arora, Rahul Deshmukh in Molecular Neurobiology
    Article 15 July 2024

  14. A comprehensive cancer center in the cloud powered by AI can reduce health disparities

    Wilfred Ngwa, Arthur Pressley, ... Kenneth Ngwa in Nature Medicine
    Article 15 July 2024

  15. Outpatient reception via collaboration between nurses and a large language model: a randomized controlled trial

    Reception is an essential process for patients seeking medical care and a critical component influencing the healthcare experience. However, current...

    Peixing Wan, Zigeng Huang, ... Er** Long in Nature Medicine
    Article 15 July 2024

  16. Effects of high-intensity interval training on cardiometabolic biomarkers in patients with prostate cancer undergoing active surveillance: a randomized controlled trial

    Purpose

    To report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in patients with prostate...

    Dong-Woo Kang, Catherine J. Field, ... Kerry S. Courneya in Prostate Cancer and Prostatic Diseases
    Article 15 July 2024

  17. Preclinical SPECT and PET: Joint EANM and ESMI procedure guideline for implementing an efficient quality control programme

    The aim of this guideline is to provide recommendations for the implementation of an effective and efficient quality control (QC) programme for SPECT...

    Christian Vanhove, Michel Koole, ... Monique Bernsen in European Journal of Nuclear Medicine and Molecular Imaging
    Article 15 July 2024

  18. A Mathematical Model for Fibrous Dysplasia: The Role of the Flow of Mutant Cells

    Fibrous dysplasia (FD) is a mosaic non-inheritable genetic disorder of the skeleton in which normal bone is replaced by structurally unsound...

    Mariia Soloviova, Juan C. Beltrán-Vargas, ... Magdalena Caballero in Bulletin of Mathematical Biology
    Article 15 July 2024

  20. The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation

    Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3...

    Jiechao Zhou, Yang ‘an Chuang, ... Wenchi Zhang in Nature Cell Biology
    Article 15 July 2024
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