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Endoplasmic reticulum stress promotes hepatocellular carcinoma by modulating immunity: a study based on artificial neural networks and single-cell sequencing
IntroductionHepatocellular carcinoma (HCC) is characterized by the complex pathogenesis, limited therapeutic methods, and poor prognosis. Endoplasmic...
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An Indigenous-informed sco** review study methodology: advancing the science of sco** reviews
BackgroundHistorically, Indigenous voices have been silent in health research, reflective of colonial academic institutions that privilege Western...
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Finite element simulation of treatment with locking plate for distal fibula fractures
An improved Finite Element Model(FEM) is applied to compare the biomechanical stability of plates with three different options in the treatment of...
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Treatment with robot-assisted gait trainer Walkbot along with physiotherapy vs. isolated physiotherapy in children and adolescents with cerebral palsy. Experimental study
BackgroundImproving walking ability is a key objective in the treatment of children and adolescents with cerebral palsy, since it directly affects...
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DBScope as a versatile computational toolbox for the visualization and analysis of sensing data from deep brain stimulation
Different neurostimulators for deep brain stimulation (DBS) come already with the ability to chronically sense local field potentials during...
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A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells
BackgroundImmunotherapies, including chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs), encounter several challenges in the...
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Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway
BackgroundTemporomandibular joint osteoarthritis (TMJOA) has a high incidence rate, but its pathogenesis remains unclear. Circadian rhythm is an...
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Decoding depression: a comprehensive multi-cohort exploration of blood DNA methylation using machine learning and deep learning approaches
The causes of depression are complex, and the current diagnosis methods rely solely on psychiatric evaluations with no incorporation of laboratory...
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Early depletion of gut microbiota shape oligodendrocyte response after traumatic brain injury
White matter injury (WMI) is thought to be a major contributor to long-term cognitive dysfunctions after traumatic brain injury (TBI). This damage...
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Synthesis and Neurobehavioral Evaluation of a Potent Multitargeted Inhibitor for the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD) poses a significant health challenge worldwide, affecting millions of individuals, and projected to increase further as the...
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Study on the preventive effect of dexmedetomidine on anesthetic associated sleep disturbance in young to middle-aged female patients undergoing hysteroscopy: a study protocol for a crossover randomized controlled trial
BackgroundPostoperative sleep disturbance has a potentially detrimental effect on postoperative recovery. Perioperative patients are affected by...
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Gras** the big picture: impact analysis of screening tools for timely referral for device-aided therapies
Several screening tools are available to assist general neurologists in the timely identification of patients with advanced Parkinson’s disease (PD)...
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Stroke heart injury: the effect of cerebral reperfusion treatment. A 3-year retrospective study
BackgroundCardiac involvement following an acute stroke (Stroke Heart Syndrome—SHS) is an established complication and it is linked to the...
