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IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation
IL-17+ γδ T cells (γδ T17) are kick-starters of inflammation due to their strict immunosurveillance of xenobiotics or cellular damages and rapid...
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Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication
Cardiovascular diseases (CVDs) are the leading causes of death and illness worldwide. While there have been advancements in the treatment of CVDs...
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Three-dimensional saturated C(sp3)-rich bioisosteres for benzene
Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are frequently associated with poor ‘drug-like’ properties,...
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LAFeBS, alive, kicking, and growing: the story continues…
This Commentary describes a call for contributions to an upcoming Special Issue (SI) of Biophysical Reviews on the Latin American Federation of...
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Intratumoral Delivery of Genetically Engineered Anti-IL-6 Trans-signaling Therapeutics
Interleukin-6 (IL-6) is a highly pro-inflammatory cytokine involved in the etiopathology of several inflammatory diseases and cancer. As so, the...
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From a focal skin issue to a systemic disease: the multifaceted nature of cold sores, novel findings
Cold sores, a viral infection caused by the herpes simplex virus, are a prevalent affliction affecting millions of people across the globe. In this...
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Pharmacokinetics and Histotoxic Profile of a Novel Azithromycin-Loaded Lipid-Based Nanoformulation
Azithromycin traditional formulations possesses poor oral bioavailability which necessitates development of new formulation with enhanced...
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Facile and cost-effective optical sensing of abamectin and ivermectin using gold nanoparticles conjugated with organosilicon compound and on cellulose filter paper
This study presents a novel, facile, and low-cost method for the separation and sensing of two closely related antiparasitic drugs, abamectin (ABM)...
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Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene
HSPB8 is a heat shock protein belonging to a family of ATP-independent stress proteins called HSPB which are present far and wide in the cells of...
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Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis
Nod-like receptor family pyrin-containing protein 3 (NLRP3) inflammasome plays a pathologic role in metabolic dysfunction-associated steatohepatitis...
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Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its...
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Genoty**-by-sequencing targets genic regions and improves resolution of genome-wide association studies in autotetraploid potato
Key messageDe novo genoty** in potato using methylation-sensitive GBS discovers SNPs largely confined to genic or gene-associated regions and...
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Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation
Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and...
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The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma...
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Exploring the complex associations among risks of malnutrition, sarcopenia, and frailty in community-dwelling older adults
BackgroundMalnutrition, sarcopenia, and frailty are age-related conditions that are associated with multiple health-related negative outcomes....
