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Current trends and future perspectives in hadron therapy: radiobiology
PurposeThe purpose of this article was to highlight current and future trends in radiobiology in an effort to move hadron therapy forward through the...
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Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial
Consumer-grade wearable technology has the potential to support clinical research and patient management. Here, we report results from the RATE-AF...
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A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we address the possibility that the...
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Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental tools that allow for the...
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The immunology of systemic lupus erythematosus
Understanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches...
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Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-Gαq Sweat Signaling Cascade
Sweat production is vital for human survival as its evaporation eases heat dissipation. Nevertheless, excessive perspiration or hyperhidrosis causes...
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HIV1 drug resistance among patients experiencing first-line treatment failure in Ethiopia: protocol for a systematic review and meta-analysis
BackgroundThe emergence of HIV drug resistance presents a substantial challenge. Current antiretroviral treatments, along with current classes, face...
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Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants
Many neurodegenerative diseases feature misfolded proteins that propagate via templated conversion of natively folded molecules. However, crucial...
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Deep source transfer learning for the estimation of internal brain dynamics using scalp EEG
Electroencephalography (EEG) provides high temporal resolution neural data for brain-computer interfacing via noninvasive electrophysiological...
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Efficacy of chemotherapy plus immune checkpoint inhibitors in patients with non-small cell lung cancer who have rare oncogenic driver mutations: a retrospective analysis
BackgroundTargeted therapy is now the standard of care in driver–oncogene-positive non-small cell lung cancer (NSCLC). Its initial clinical effects...
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Ile-Pro-Pro attenuates sympathetic activity and hypertension
Isoleucine-proline-proline (Ile-Pro-Pro, IPP) is a natural food source tripeptide that inhibits angiotensin-converting enzyme (ACE) activity. The aim...
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The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion in annual healthcare expenditures only in the United...
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Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects
Immunotherapies for cancer, specifically immune checkpoint inhibition (ICI), have shown potential in reactivating the body’s immune response against...
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miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1
BackgroundSpinal cord injury (SCI) is characterized by extensive demyelination and inflammatory responses. Facilitating the clearance of lipid...
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Food security among black breast cancer survivors in Maryland: insights from an online pilot study
PurposeFood security, and reliable access to nutritious food, is essential for maintaining health yet remains elusive for many, including U.S....
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Pure epidural extraosseous cavernous hemangioma with thoracic myelopathy: case report and review of literature
IntroductionPure epidural spinal cavernous hemangiomas are rare, benign vascular tumors that account for approximately 4% of all spinal epidural...
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Burosumab Efficacy and Safety in Patients with X-Linked Hypophosphatemia: Systematic Review and Meta-analysis of Real-World Data
To assess the efficacy and safety of burosumab in children and adults with X-linked hypophosphatemia based on real-world evidence. MEDLINE (via...
