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Unveiling the translational dynamics of lychee (Litchi chinesis Sonn.) in response to cold stress
Cold stress poses a significant threat to the quality and productivity of lychee ( Litchi chinensis Sonn . ). While previous research has extensively...
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Vitamin C Alleviates Neurobehavioral Deficits, IGF1 Expression, and Neuronal Damage Induced by Chronic Social Isolation Stress in the Hippocampus of Adult Male Rats
Social isolation stress (SIS) is associated with emotional and cognitive deficits. Here, we examined the impact of prolonged treatment with vitamin C...
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A dynamic subpopulation of CRISPR–Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage
Many CRISPR–Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein) systems, which provide bacteria with...
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Obesity-induced inflammation: connecting the periphery to the brain
Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire body. This sustained inflammatory state disrupts the...
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Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of diverse organic solutes across...
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Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and...
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Structural basis of tethered agonism and G protein coupling of protease-activated receptors
Protease-activated receptors (PARs) are a unique group within the G protein-coupled receptor superfamily, orchestrating cellular responses to...
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Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here...
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Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection
Arthropod-borne pathogens are responsible for hundreds of millions of infections in humans each year. The blacklegged tick, Ixodes scapularis , is the...
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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications
Approved vaccines are effective against severe COVID-19, but broader immunity is needed against new variants and transmission. Therefore, we...
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Multi-layer Bundling as a New Approach for Determining Multi-scale Correlations Within a High-Dimensional Dataset
The growing complexity of biological data has spurred the development of innovative computational techniques to extract meaningful information and...
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Neutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We...
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The potential application of Czenspinskia transversostriata in biological control
Phytoseiid predatory mites are one of the most important groups of biocontrol agents, commonly used in biological control. The ability to produce...
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Thiolated chitosan nanoparticles encapsulated nisin and selenium: antimicrobial/antibiofilm/anti-attachment/immunomodulatory multi-functional agent
BackgroundThe increase in the resistance of bacterial strains to antibiotics has led to research into the bactericidal potential of non-antibiotic...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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Traditional Herbal Remedies Used in the Management of Urolithiasis by the Tribals of Purulia District, West Bengal, India
The tribal populations in Purulia district directly or indirectly rely on medicinal plants for their basic medical needs. Urolithiasis is the...
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Identification and characterization of specific motifs in effector proteins of plant parasites using MOnSTER
Plant pathogens cause billions of dollars of crop loss every year and are a major threat to global food security. Identifying and characterizing...
