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Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for...
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Effects of a staff-led multicomponent physical activity intervention on preschooler's fundamental motor skills and physical fitness: The ACTNOW cluster-randomized controlled trial
BackgroundFundamental motor skills (FMS) and physical fitness (FIT) play important roles in child development and provide a foundation for lifelong...
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Device-measured sedentary time and intensity-specific physical activity in relation to all-cause and cardiovascular disease mortality: the UK Biobank cohort study
Background and aimsUnderstanding the amounts of intensity-specific movement needed to attenuate the association between sedentary time and mortality...
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Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling
Dopaminergic neurons play a crucial role in associative learning, but their capacity to regulate behavior on subsecond timescales remains debated. It...
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Comparing national device-based physical activity surveillance systems: a systematic review
BackgroundPhysical activity surveillance systems are important for public health monitoring but rely mostly on self-report measurement of physical...
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Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner
Epidemiological studies link exposure to viral infection during pregnancy, including influenza A virus (IAV) infection, with increased incidence of...
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Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
Current literature suggests that people with psychiatric disorders have a higher risk of COVID-19 infection and a worse prognosis of the disease. We...
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A feature-specific prediction error model explains dopaminergic heterogeneity
The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error (RPE) is among the great successes of computational...
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Day-after impact of simulated rival encounter in the common cuckoo
Studies show that the common cuckoo exhibits a strong vocal response to rival playback. In this study, we aimed to assess if males would more eagerly...
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Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank
Suicide is a global public health challenge, yet considerable uncertainty remains regarding the associations of both behaviour-related and...
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Neuroglia in cognitive reserve
The concept of cognitive reserve was born to account for the disjunction between the objective extent of brain damage in pathology and its clinical...
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A discrete subpopulation of PFC-LHb neurons govern cocaine place preference
Addiction is a complex behavioral disorder characterized by compulsive drug-seeking and drug use despite harmful consequences. The prefrontal cortex...
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Life’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study
BackgroundEvidence has shown that the individual metrics in Life’s Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the...
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Metabolite Profiling of Alectryon Tomentosus Leaf Extract via GC/MS Analysis and Its Renal Protective Effect
Alectryon is a genus of trees in the family Sapindaceae that occurs in the rainforests of Australia and vast areas of Asian continent. In the present...