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Impact of medicine shortages on hospital practice: role of a multidisciplinary medicine shortages team
Medicine shortages are an increasing issue, with broad public health implications for patients, health professionals and institutions. Despite...
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Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study
BackgroundAnticholinergic medications are now widely acknowledged for their unfavorable risk-to-benefit profile owing to their adverse effects....
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Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes
BackgroundThe genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and...
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The impact of codeine rescheduling on non-opioid analgesic use by people who regularly use codeine: a prospective cohort study
BackgroundCodeine was rescheduled in Australia to prescription only in February 2018. Initial studies reported an increase in population level...
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Kalanchoe pinnata (Lam.) Pers. Leaf ethanolic extract exerts selective anticancer activity through ROS-induced apoptotic cell death in human cancer cell lines
BackgroundThe leaves of Kalanchoe pinnata (Lam.) Pers. ( K. pinnata ), a succulent plant native to tropical regions, are used as a medicinal...
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A comparison of brown fat tissue related hormone levels in metabolically healthy and unhealthy individuals with obesity
PurposeOne of the key functions of brown adipose tissue is its positive impact on metabolism. This study aimed to examine the potential involvement...
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Obstetric and perinatal outcomes in women with cerebrovascular accident vs. transient ischemic attack: an evaluation of a population database
PurposeCerebrovascular accidents (CVAs) and transient ischemic attacks (TIAs) are uncommon neurologic events in women of childbearing age. We aimed...
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Treatment and management of medullary thyroid microcarcinoma: a 10-year retrospective study from a single center
ObjectiveTo explore individualized treatment and management methods for medullary thyroid microcarcinoma (MTMC).
MethodsClinical data of patients...
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What does “urgency” mean when prioritizing cancer treatment? Results from a qualitative study with German oncologists and other experts during the COVID-19 pandemic
PurposeCancer care in Germany during the COVID-19 pandemic was affected by resource scarcity and the necessity to prioritize medical measures. This...
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Cytogenomic description of a Mexican cohort with differences in sex development
BackgroundDifferences in Sex Development (DSD) is a heterogeneous group of congenital alterations that affect inner and/or outer primary sex...
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Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans
BackgroundWe recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These...
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Challenges in the diagnosis and treatment of pure non-gestational uterine choriocarcinoma in a child: a case report
BackgroundDiagnosing non-gestational uterine choriocarcinoma in children is challenging because of its rarity and nonspecific imaging findings....
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Deep transfer learning for detection of breast arterial calcifications on mammograms: a comparative study
IntroductionBreast arterial calcifications (BAC) are common incidental findings on routine mammograms, which have been suggested as a sex-specific...
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YAP/TAZ interacts with RBM39 to confer resistance against indisulam
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential...
