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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial...
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The role of histamine and its receptors in breast cancer: from pathology to therapeutic targets
Breast cancer is the most common malignancy in women, and despite the development of new treatment methods and the decreasing mortality rate in...
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Death following cylindrical battery ingestion associated with toxic manganese levels
Cases of battery ingestion are well documented in the scientific literature, especially concerning button cell battery ingestion in children. In this...
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A novel case of ulnar nerve compression neuropathy with co-existing accessory flexor carpi ulnaris and accessory abductor digiti minimi
There are numerous cases reported of the accessory muscles of the hand and wrist in surgical, cadaveric, and imaging-based studies. Anatomical muscle...
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Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR...
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Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia
ObjectiveFatty infiltration of skeletal muscle (Myosteatosis) is associated with increased frailty, decreased muscle and mobility function, which...
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Clinicopathological Factors as Predictors for Establishment of Patient Derived Head and Neck Squamous Cell Carcinoma Organoids
IntroductionPatient derived organoids (PDOs) are 3D in vitro models and have shown to better reflect patient and tumor heterogeneity than...
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Sudden unexpected death after initial infusion of rituximab for Waldenström macroglobulinemia/lymphoplasmacytic lymphoma: an autopsy case
BackgroundWaldenström’s macroglobulinemia (WM) is defined as a lymphoplasmacytic lymphoma (LPL) involving the bone marrow (BM) with presence of IgM...
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Intraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically
BackgroundPrevious studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative...
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Central Myoepithelioma of the Maxilla
Myoepithelioma is a benign salivary gland tumor. Central myoepitheliomas are very rare. The aim of this report was to describe a case of maxillary...
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A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication
The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for...
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Pure Apocrine Intraductal Carcinoma of Salivary Glands: Reassessment of Molecular Underpinnings and Behavior
BackgroundIntraductal carcinoma (IDC) of the salivary glands is a confounding entity, our understanding of which continues to evolve. At least four...
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Whole-body low-dose computed tomography in patients with newly diagnosed multiple myeloma predicts cytogenetic risk: a deep learning radiogenomics study
ObjectiveTo develop a whole-body low-dose CT (WBLDCT) deep learning model and determine its accuracy in predicting the presence of cytogenetic...
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Thymus transplantation as immunotherapy for the enhancement and/or correction of T cell function
The thymus is where T cells, among the most important immune cells involved in biological defense and homeostasis, are produced and developed. The...
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Dose-dependent effects of cobalt chloride supplementation in a rat model of acetic acid-induced ulcerative colitis
Several recent studies have shown that hypoxia preconditioning, often mimicked by sub-toxic levels of cobalt, can protect body tissues against...
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Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity
CD8 + T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane...
