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Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Background & aimsPatients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed...
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Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study
BackgroundWe previously demonstrated the applicability of the concept of “platinum sensitivity” in recurrent endometrial cancer. Although immune...
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An international delphi survey and consensus meeting to define the risk factors for ureteral stricture after endoscopic treatment for urolithiasis
PurposeIatrogenic ureteral strictures (US) after endoscopic treatment for urolithiasis represent a significant healthcare concern. However,...
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Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury
PurposeNeratinib, a small-molecule tyrosine kinase inhibitor (TKI) that irreversibly binds to human epidermal growth factor receptors 1, 2 and 4...
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Changes in skeletal muscle function during chemotherapy and related factors in patients with acute leukemia
IntroductionSkeletal muscle function is an important prognostically relevant indicator in patients with acute leukemia (AL), but skeletal dysfunction...
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LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway
PurposeLong noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with...
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Low dose of dexamethasone combined with netupitant and palonosetron in preventing nausea and vomiting in breast cancer patients induced by anthracycline drugs
BackgroundTo study the effects of various courses of dexamethasone (DEX) combined with 5-HT3 receptor antagonists (RA) and NK-1 RA in suppressing...
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Elemental Diet as a Therapeutic Modality: A Comprehensive Review
Elemental diets have been employed for the management of various diseases for over 50 years, with several mechanisms mediating their beneficial...
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Dose prescription for stereotactic body radiotherapy: general and organ-specific consensus statement from the DEGRO/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery
Purpose and objectiveTo develop expert consensus statements on multiparametric dose prescriptions for stereotactic body radiotherapy (SBRT) aligning...
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Recent Advances of Neoadjuvant Immunotherapy for Urothelial Bladder Cancer
Urothelial bladder cancer is one of the most common malignant tumors of the urinary system, which accounts for 90~95% of urothelial carcinoma....
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Hepatocellular Carcinoma in Asia: Physician and Patient Perspectives on Surveillance, Diagnosis, and Treatment
PurposeIn several Asian countries, hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. HCC risk factors in Asia differ from those...
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Outcomes of deep venous thrombosis management and associated factors among patients in tertiary hospitals in Addis Ababa, Ethiopia: a multicenter retrospective cohort study
BackgroundPulmonary embolism (PE) and deep venous thrombosis (DVT) are the two most important manifestations of venous thromboembolism (VTE). DVT...
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Clinical characteristics and prognosis of pancreatitis associated with immune checkpoint inhibitors
Background and objectiveImmune checkpoint inhibitors (ICIs) have shown remarkable efficacy against various cancers in clinical practice. However,...
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Clip** the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial
BackgroundFor patients with clinically node-positive (cN+) breast cancer undergoing neoadjuvant chemotherapy (NAC), retrieving previously clipped,...
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
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Patient attitudes and experiences towards exercise during oncological treatment. A qualitative systematic review
PurposeExercise and physical activity (PA) during oncological treatment have many benefits. However, PA levels and adherence are often low. This...
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Effect of dipeptidyl peptidase-4 inhibitors on tumor necrosis factor alpha levels in patients with type 2 diabetes mellitus
AimsDipeptidyl peptidase-4 inhibitors (DPP-4i) served as oral antidiabetic agents for treatment of type 2 diabetes mellitus (T2DM). Although an...
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A DPC Database Study on the Safety of Atezolizumab/Carboplatin/Etoposide in Extensive-Disease Small Cell Lung Cancer in Japanese Patients
IntroductionAtezolizumab, carboplatin, and etoposide (ACE) therapy is a standard of care for extensive-disease small cell lung cancer (SCLC);...
