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Association between Parkinson’s disease and cardiovascular disease mortality: a prospective population-based study from NHANES
Background and aimConflicting results have been reported on the association between Parkinson's disease (PD) and cardiovascular disease (CVD)...
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Non-O blood types are associated with a greater risk of large artery atherosclerosis stroke and dysregulation of cholesterol metabolism: an observational study
BackgroundPrevious research on ABO blood types and stroke has been controversial, predominantly suggesting heightened risk of stroke in non-O blood...
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RIP3 orchestrates oxidative stress and pyroptosis in doxorubicin-induced cardiotoxicity through regulation of AKT/Nrf2 signaling cascade
This study was designed to explore the role of RIP3 in DOX-induced cardiotoxicity and its underlying molecular mechanisms. Our results demonstrate...
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Evaluation of the ability of insulin resistance and lipid-related indices to predict the presence of NAFLD in obese adolescents
BackgroundNonalcoholic fatty liver disease (NAFLD) has become an important health issue in adolescents. Although several parameters and indices have...
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Ribosomal proteins: the missing piece in the inflammation puzzle?
Ribosomal proteins (RPs) are constituents of macromolecular machinery, ribosome that translates genetic information into proteins. Besides ribosomal...
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Lysosomal cation channel TRPML1 suppression sensitizes acute myeloid leukemia cells to chemotherapeutics by inhibiting autophagy
Despite the implementation of novel therapeutic regimens and extensive research efforts, chemoresistance remains a formidable challenge in the...
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Role of plasma fatty acid in age-related macular degeneration: insights from a mendelian randomization analysis
BackgroundAn imbalance in lipid metabolism has been linked to the development of AMD, but the causal relationship between AMD and plasma fatty acids...
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Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
BackgroundKetogenic diets are increasingly popular for addressing obesity, but their impacts on the gut microbiota and metabolome remain unclear....
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Serum lipid metabolism characteristics and potential biomarkers in patients with unilateral sudden sensorineural hearing loss
BackgroundGlycerophospholipids (GPLs) are essential for cell membrane structure and function. Sphingomyelin and its metabolites regulate cell growth,...
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The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets
Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes with high morbidity and mortality. Ferroptosis is a form of...
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Unveiling the therapeutic promise: exploring Lysophosphatidic Acid (LPA) signaling in malignant bone tumors for novel cancer treatments
Malignant bone tumors, including primary bone cancer and metastatic bone tumors, are a significant clinical challenge due to their high frequency of...
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Early-life bisphenol A exposure causes neuronal pyroptosis in juvenile and adult male rats through the NF-κB/IL-1β/NLRP3/caspase-1 signaling pathway: exploration of age and dose as effective covariates using an in vivo and in silico modeling approach
Bisphenol A (BPA), a common endocrine-disrupting chemical, is found in a wide range of home plastics. Early-life BPA exposure has been linked to...
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Association between triglyceride glucose index-related indices with gallstone disease among US adults
BackgroundTriglyceride glucose (TyG) index combined with obesity-related indicators [triglyceride glucose-body mass index (TyG-BMI), triglyceride...
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Unraveling the controversy between fasting and nonfasting lipid testing in a normal population: a systematic review and meta-analysis of 244,665 participants
BackgroundThe final decision to fast or not fast for routine lipid profile examination in a standard, healthy population is unclear. Whereas the...
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Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases
BackgroundTraumatic brain injury (TBI) causes neuroinflammation and can lead to long-term neurological dysfunction, even in cases of mild TBI (mTBI)....
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Deciphering the lipid–cancer nexus: comprehensive Mendelian randomization analysis of the associations between lipid profiles and digestive system cancer susceptibility
BackgroundDigestive system cancers represent a significant global health challenge and are attributed to a combination of demographic and lifestyle...
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Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
BackgroundNonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying...
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Gender-specific accuracy of lipid accumulation product index for the screening of metabolic syndrome in general adults: a meta-analysis and comparative analysis with other adiposity indicators
BackgroundLipid accumulation product (LAP) is a novel predictor index of central lipid accumulation associated with metabolic and cardiovascular...
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Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
BackgroundLipids, including phospholipids and bile acids, exert various signaling effects and are thought to contribute to the development of...
