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Expression genome-wide association study identifies key regulatory variants enriched with metabolic and immune functions in four porcine tissues
BackgroundIntegration of high throughput DNA genoty** and RNA-sequencing data enables the discovery of genomic regions that regulate gene...
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Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress
BackgroundIn humans, ACTN2 mutations are identified as highly relevant to a range of cardiomyopathies such as DCM and HCM, while their association...
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Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population
BackgroundColorectal cancer (CRC) is the 3rd most common cancer in the world and colonic carcinogenesis is a multifactorial disease that involves...
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Designing and expression of novel recombinant fusion protein for efficient antigen screening of SARS-CoV-2
Corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), claimed millions globally....
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Existence of rare actinobacterial forms in the Indian sector of Southern Ocean: 16 S rRNA based metabarcoding study
The significance of the Southern Ocean (SO) as a sink of atmospheric CO 2 and other greenhouse gases is well established. Earlier studies have...
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Modulation of gene expression in immune-related organs by in ovo stimulation with probiotics and prophybiotics in broiler chickens
In ovo stimulation has been studied intensively as an alternative to antibiotic use in poultry production. We investigated the potential use of a...
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Herbidomicins, two pairs of polyketide tautomers produced by an actinomycete of the genus Herbidospora
Herbidospora is one of the underexplored actinomycete genera from which only a limited number of secondary metabolites are reported. In our...
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Two newly established and mutually related subfamilies GH13_48 and GH13_49 of the α-amylase family GH13
AbstractCurrently, the main α-amylase family GH13 has been divided into 47 subfamilies in CAZy, with new subfamilies regularly emerging. The present i...
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Genome-wide analysis of histone modifications can contribute to the identification of candidate cis-regulatory regions in the threespine stickleback fish
BackgroundCis -regulatory mutations often underlie phenotypic evolution. However, because identifying the locations of promoters and enhancers in...
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Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink
The recent chromosome-based genome assembly and the newly developed 70K single nucleotide polymorphism (SNP) array for American mink ( Neogale vison )...
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A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus
Medicinal mushrooms, such as Taiwanofungus camphoratus , Inonotus obliquus , and Tropicoporus linteus , have been used in traditional medicine for...
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TFscope: systematic analysis of the sequence features involved in the binding preferences of transcription factors
Characterizing the binding preferences of transcription factors (TFs) in different cell types and conditions is key to understand how they...
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Antibacterial activity and biosynthetic potential of Streptomyces sp. PBR19, isolated from forest rhizosphere soil of Assam
An Actinomycetia isolate, designated as PBR19, was derived from the rhizosphere soil of Pobitora Wildlife Sanctuary (PWS), Assam, India. The isolate,...
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sciMET-cap: high-throughput single-cell methylation analysis with a reduced sequencing burden
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust,...
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A new standardization for the use of chicken embryo: selection of target from the phage display library and infection
AbstractThe filamentous bacteriophage M13KO7 (M13) is the most used in phage display (PD) technology and, like other phages, has been applied in...
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COQ7 splice site variant causing a spastic paraparesis phenotype in siblings
The COQ7 gene is one of the causative genes for primary COQ10 deficiency-related disorders. OMIM-related phenotypes include severe...
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An affordable detection system based on RT-LAMP and DNA-nanoprobes for avian metapneumovirus
AbstractAirborne animal viral pathogens can rapidly spread and become a global threat, resulting in substantial socioeconomic and health...
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Enzymatic degradation of polylactic acid (PLA)
AbstractEnvironmental concerns arising from the increasing use of polluting plastics highlight polylactic acid (PLA) as a promising eco-friendly...
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Optimization of concentrations of different n-3PUFAs on antioxidant capacity in mouse hepatocytes
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), mainly including α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid...
