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Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury
BackgroundHematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect...
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Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a...
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Diverse functions and pathogenetic role of Crumbs in retinopathy
The Crumbs protein (CRB) family plays a crucial role in maintaining the apical–basal polarity and integrity of embryonic epithelia. The family...
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IL-17 in wound repair: bridging acute and chronic responses
Chronic wounds, resulting from persistent inflammation, can trigger a cascade of detrimental effects including exacerbating inflammatory cytokines,...
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Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis
BackgroundColorectal cancer (CRC) commonly exhibits tolerance to cisplatin treatment, but the underlying mechanisms remain unclear. Within the tumor...
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Endothelial cell-derived extracellular vesicles modulate the therapeutic efficacy of mesenchymal stem cells through IDH2/TET pathway in ARDS
BackgroundAcute respiratory distress syndrome (ARDS) is a severe and fatal disease. Although mesenchymal stem cell (MSC)-based therapy has shown...
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Hydrothermal infra-red (HT-IR): the most effective technology for enhancing the shelf-life of pearl millet flour without compromising with the nutrient density and flour quality
Pearl millet, considered as nutri-cereal, has better nutritional composition and quality, as compared to other cereals. Though, it is less popular...
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Molecular mechanisms of aging and anti-aging strategies
Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the...
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The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling
BackgroundT-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular...
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An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells
BackgroundTo elucidate the mechanism of dysfunction of tolerogenic dendritic cells (DCs) is of significance. Telomerase involves the regulation of...
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APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition
BackgroundIn addition to functioning as a precise monitoring mechanism in cell cycle, the anaphase-promoting complex/cyclosome (APC/C) is reported to...
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Extracellular vesicles promote migration despite BRAF inhibitor treatment in malignant melanoma cells
Extracellular vesicles (EVs) constitute a vital component of intercellular communication, exerting significant influence on metastasis formation and...
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Conversion of dendritic cells into tolerogenic or inflammatory cells depends on the activation threshold and kinetics of the mTOR signaling pathway
BackgroundRestoring impaired peripheral immune tolerance is the primary challenge in treating autoimmune diseases. Our previous research demonstrated...
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O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology
O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and...
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Metabolic self-feeding in HBV-associated hepatocarcinoma centered on feedback between circulation lipids and the cellular MAPK/mTOR axis
IntroductionHepatitis B Virus (HBV) is widely recognized as a “metabolic virus” that disrupts hepatic metabolic homeostasis, rendering it one of the...
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HvVDAC1 interacts with HvSAMS1 and is predominantly expressed during germination and grain development
Voltage-dependent anion channels (VDACs) are known to be involved in the transport of molecules across the outer mitochondrial membrane....
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Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB
BackgroundWhile de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular...
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Tumor derived exosomal ENTPD2 impair CD8+ T cell function in colon cancer through ATP-adenosine metabolism reprogramming
BackgroundExtracellular ATP–AMP–adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the...
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Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion
BackgroundDiabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil...
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Bcl-2 dependent modulation of Hippo pathway in cancer cells
IntroductionBcl-2 and Bcl-xL are the most studied anti-apoptotic members of Bcl-2 family proteins. We previously characterized both of them, not only...
