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Decoding the chemical repertoire, antimicrobial synergy, and antioxidant mastery of banana pulp and peel extracts
This study investigates the antimicrobial, antioxidant, and phytochemical properties of banana extracts from both ripe and unripe pulp and peel,...
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Short-term response of primary human meniscus cells to simulated microgravity
BackgroundMechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-inductive potential...
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Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
BackgroundTriple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high...
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Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in...
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Extracellular vesicles released by host epithelial cells during Pseudomonas aeruginosa infection function as homing beacons for neutrophils
BackgroundPseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause sight threatening infections in the eye and fatal infections in...
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Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Anti-programmed death 1/programmed death ligand 1 (anti-PD-1/PD-L1) antibodies exert significant antitumor effects by overcoming tumor cell immune...
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SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation
Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for...
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Reciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer
BackgroundEndocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal....
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The role of KLRG1: a novel biomarker and new therapeutic target
Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subsets that downregulates the...
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Programmed cell death disrupts inflammatory tumor microenvironment (TME) and promotes glioblastoma evolution
Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year...
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A novel approach to alleviate acetaminophen-induced hepatotoxicity with hybrid balloon flower root-derived exosome-like nanoparticles (BDEs) with silymarin via inhibition of hepatocyte MAPK pathway and apoptosis
IntroductionBalloon flower root-derived exosome-like nanoparticles (BDEs) have recently been proposed as physiologically active molecules with no...
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Activation of kappa opioid receptor suppresses post-traumatic osteoarthritis via sequestering STAT3 on the plasma membrane
ObjectiveKappa opioid receptor (KOR) signaling is involved in joint development and inflammation in Osteoarthritis (OA), while the biochemical...
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Biomechanics of circulating cellular and subcellular bioparticles: beyond separation
Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellular fractions. Numerous...
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Colletotrichum falcatum infection influences the abundance of sucrose transporters and disease resistant proteins in sugarcane stalk
Sugarcane, commercially cultivated for the production of sucrose, is constantly confronted by Colletotrichum falcatum which is accountable for the...
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Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice
BackgroundHRAS KO /NRAS KO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a...
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Enhancing the aervine and methylaervine production in in vitro cultures of Aerva javanica (Burm. F.) Schult via elicitors and Agrobacterium rhizogenes-mediated hairy root cultures
An understanding of plant secondary metabolites may prove to be important for novel drug development. The objective of this investigation was to...
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Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously...
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CRISPR/Cas9 gene editing: a novel strategy for fighting drug resistance in respiratory disorders
Respiratory disorders are among the conditions that affect the respiratory system. The healthcare sector faces challenges due to the emergence of...
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Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease
BackgroundKawasaki disease (KD) is an immune vasculitis of unknown origin, characterized by transient inflammation. The activation of the cGAS-STING...
