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CRISPR-Cas9-mediated deletion enhancer of MECOM play a tumor suppressor role in ovarian cancer
MDS1 and EVI1 complex locus (MECOM), a transcription factor encoding several variants, has been implicated in progression of ovarian cancer. The...
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Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and...
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Fertilization regime changes rhizosphere microbial community assembly and interaction in Phoebe bournei plantations
AbstractFertilizer input is one of the effective forest management practices, which improves soil nutrients and microbial community compositions and...
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TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
BackgroundThe neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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Alpha-expansins: more than three decades of wall creep and loosening in fruits
Expansins are proteins without catalytic activity, but able to break hydrogen bonds between cell wall polysaccharides hemicellulose and cellulose....
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TGF-β1-Induced LINC01094 promotes epithelial-mesenchymal transition in hepatocellular carcinoma through the miR-122-5p/TGFBR2–SAMD2–SMAD3 Axis
Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. It has been proven that long non-coding RNAs (lncRNAs) play an essential...
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Assessment of Elemental Deficiency of Crossbred Dairy Cows and Mineral Composition in Natural Feed and Nutritional Supplements in the Northern and Northwestern Provinces in Sri Lanka
This study assessed the elemental status of cross-bred dairy cows in small holder farms in Sri Lanka, with the aim to establish the elemental...
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Polycomb function in early mouse development
Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial stages of embryo development. Among these factors, the...
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Determination of Selected Metals and Metalloids in Different Types of Rice by Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES)
Pantanal is a unique biome located in Brazil, with diverse fauna and flora, being home to native species such as the rice types Oryza latifolia and Ory...
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Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma
The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant...
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Correlation Between Severity of Schizophrenia with Certain Trace Elements and TNF-α Gene Expression and Its Circulatory Level in the Population of Western India
This cross-sectional study aimed to assess serum trace element (TE) concentrations, TNF-α gene expression, protein levels in schizophrenia (SZ)...
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Elevated Metal Levels in U.S. Honeys: Is There a Concern for Human Health?
Honey is a bioactive food used for millennia to improve health and treat diseases. More recently, researchers employ honey as a tool to assess local...
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Blockade of PD-1 and TIM-3 Ameliorates CD8+ T Cell Exhaustion in a Mouse Model of Chronic Myeloid Leukemia
The immune system plays a pivotal role in controlling chronic myeloid leukemia (CML). CD8 + T cell exhaustion results in reduced effectiveness of T...
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Identification of tomato F-box proteins functioning in phenylpropanoid metabolism
Phenylpropanoids, a class of specialized metabolites, play crucial roles in plant growth and stress adaptation and include diverse phenolic compounds...
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Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA
Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR) with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base...
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Conversion of polyploid and alloploid Saccharomyces sensu stricto strains to leu2 mutants by genome DNA editing
AbstractA large number of recombinant plasmids for the yeast Saccharomyces cerevisiae have been constructed and accumulated over the past four...
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Template-independent enzymatic synthesis of RNA oligonucleotides
RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver...
