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Template-independent enzymatic synthesis of RNA oligonucleotides
RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver...
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Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measurements in controlled clinical...
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The nature of the last universal common ancestor and its impact on the early Earth system
The nature of the last universal common ancestor (LUCA), its age and its impact on the Earth system have been the subject of vigorous debate across...
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Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA
Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR) with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base...
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Deep 3D histology powered by tissue clearing, omics and AI
To comprehensively understand tissue and organism physiology and pathophysiology, it is essential to create complete three-dimensional (3D) cellular...
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Phytoseiid mites benefited from organic fertilization by increasing the population of Tyrophagus mites in apple orchards
This study explores sustainable agricultural practices by examining the role of organic materials in enhancing native predatory mites for controlling...
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Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder
In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that...
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Heritability of functional gradients in the human subcortico-cortical connectivity
The human subcortex plays a pivotal role in cognition and is widely implicated in the pathophysiology of many psychiatric disorders. However, the...
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Comprehensive analysis of the Xya riparia genome uncovers the dominance of DNA transposons, LTR/Gypsy elements, and their evolutionary dynamics
Transposable elements (TEs) are DNA sequences that can move or replicate within a genome, and their study has become increasingly important in...
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Nesting biology of Tetrapedia amplitarsis (Hymenoptera: Apidae: Tetrapediini)
Tetrapedia amplitarsis is an oil-collecting solitary bee that nests in pre-existing cavities and differs from the other species of the genus in...
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Green synthesis of Agaricus avensis-mediated silver nanoparticles for improved catalytic efficiency of tyrosine hydroxylase towards potential biomedical implications
The present study deals with the bio-fabrication of AgA-AgNPs utilizing edible mushroom Agaricus arvensis as a reductant for improved stability and...
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Replicase gene mediated RNA silencing mechanism confers resistance against groundnut bud necrosis virus in tomato (Lycopersicon esculentum Mill.)
Groundnut bud necrosis virus (GBNV), a member of the genus Orthotospovirus , is the most devastating pathogen causing bud blight of tomato and causes...
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Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
In spite of its essential role in culture media, the precise influence of lactate on early mouse embryonic development remains elusive. Previous...
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Biogenic synthesis and characterization of gold nanoparticles using transformed mesophilic Escherichia coli BL21 and thermophilic Thermus thermophilus HB27
Gold nanoparticles have numerous applications, many of which are notable in industries. The biosynthesis of gold nanoparticles offers an easy,...
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Expression genome-wide association study identifies key regulatory variants enriched with metabolic and immune functions in four porcine tissues
BackgroundIntegration of high throughput DNA genoty** and RNA-sequencing data enables the discovery of genomic regions that regulate gene...
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Composition of the whiteflies microbiome in populations with and without insecticide applications in Yucatan Mexico
The whitefly Bemisia tabaci (Gennadius) has coevolved with intracellular endosymbiotic bacteria that help supplement their nutrient-poor diets with...
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YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8+ T lymphocytes
Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have...
