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Correlation Between Severity of Schizophrenia with Certain Trace Elements and TNF-α Gene Expression and Its Circulatory Level in the Population of Western India
This cross-sectional study aimed to assess serum trace element (TE) concentrations, TNF-α gene expression, protein levels in schizophrenia (SZ)...
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Elevated Metal Levels in U.S. Honeys: Is There a Concern for Human Health?
Honey is a bioactive food used for millennia to improve health and treat diseases. More recently, researchers employ honey as a tool to assess local...
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Blockade of PD-1 and TIM-3 Ameliorates CD8+ T Cell Exhaustion in a Mouse Model of Chronic Myeloid Leukemia
The immune system plays a pivotal role in controlling chronic myeloid leukemia (CML). CD8 + T cell exhaustion results in reduced effectiveness of T...
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Polycomb function in early mouse development
Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial stages of embryo development. Among these factors, the...
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Determination of Selected Metals and Metalloids in Different Types of Rice by Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES)
Pantanal is a unique biome located in Brazil, with diverse fauna and flora, being home to native species such as the rice types Oryza latifolia and Ory...
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Identification of tomato F-box proteins functioning in phenylpropanoid metabolism
Phenylpropanoids, a class of specialized metabolites, play crucial roles in plant growth and stress adaptation and include diverse phenolic compounds...
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Extrachromosomal circular DNA promotes prostate cancer progression through the FAM84B/CDKN1B/MYC/WWP1 axis
BackgroundExtrachromosomal circular DNA (eccDNA), a kind of circular DNA that originates from chromosomes, carries complete gene information,...
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Polyphenols and terpenoids derived from Ocimum species as prospective hepatoprotective drug leads: a comprehensive mechanistic review
The hepatic regulatory role in metabolism involves exposure to a diverse array of xenobiotic compounds leading to the potential accumulation of...
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A novel homozygous missense TTC12 variant identified in an infertile Pakistani man with severe oligoasthenoteratozoospermia and primary ciliary dyskinesia
TTC12 is a cytoplasmic and centromere-localized protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both...
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Giant milkweed: a comprehensive review of chemical constituents and their insecticidal properties
Calotropis gigantea (L.) W.T. Aiton, a common barren land weed, referred to as Giant Milkweed, has attracted considerable attention due to its rich...
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Airways Relaxant and Antiasthmatic Activity of Aconitum heterophyllum Wall ex Royle. Roots: A Mechanistic Insight
Aconitum heterophyllum Wall ex Royle. (Ranunculaceae) is a traditional medicinal herb that has shown extensive pharmacological potential to treat...
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Nanoarchitectonics for synergistic activity of multimetallic nanohybrids as a possible approach for antimicrobial resistance (AMR)
The global threat posed by antimicrobial resistance (AMR) to public health is an immensurable problem. The effectiveness of treating infections would...
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Oxidative stress across multiple tissues in house sparrows (Passer domesticus) acclimated to warm, stable cold, and unpredictable cold thermal treatments
With climate change increasing not just mean temperatures but the frequency of cold snaps and heat waves, animals occupying thermally variable areas...
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Dramatic loss of microbial viability in bentonite exposed to heat and gamma radiation: implications for deep geological repository
Bentonite is an integral part of the engineered barrier system (EBS) in deep geological repositories (DGR) for nuclear waste, but its indigenous...
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Navigating the complexity of p53-DNA binding: implications for cancer therapy
AbstractThe tumor suppressor protein p53, a transcription factor playing a key role in cancer prevention, interacts with DNA as its primary means of...
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Biodegradation of the cyanobacterial toxin anatoxin-a by a Bacillus subtilis strain isolated from a eutrophic lake in Saudi Arabia
Anatoxin-a (ATX-a) is a neurotoxin produced by some species of cyanobacteria. Due to its water solubility and stability in natural water, it could...
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Green synthesis of Agaricus avensis-mediated silver nanoparticles for improved catalytic efficiency of tyrosine hydroxylase towards potential biomedical implications
The present study deals with the bio-fabrication of AgA-AgNPs utilizing edible mushroom Agaricus arvensis as a reductant for improved stability and...
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Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
In spite of its essential role in culture media, the precise influence of lactate on early mouse embryonic development remains elusive. Previous...
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