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Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the causative factors of...
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MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for spinal cord injury (SCI), but improving the neurogenic potential...
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Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia (XLH)
X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads to hypophosphatemia and...
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Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis
Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic...
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Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing
Dental primary afferent (DPA) neurons and proprioceptive mesencephalic trigeminal nucleus (MTN) neurons, located in the trigeminal ganglion and the...
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Oral squamous cell carcinomas: state of the field and emerging directions
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and...
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Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion
While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), the underlying mechanisms...
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Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry
The dental operative microscope has been widely employed in the field of dentistry, particularly in endodontics and operative dentistry, resulting in...
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Maxillary sinus floor augmentation: a review of current evidence on anatomical factors and a decision tree
Maxillary sinus floor augmentation using lateral window and crestal technique is considered as predictable methods to increase the residual bone...
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Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development
Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its...
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Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma
Pleomorphic adenoma (PA) is the most common benign tumour in the salivary gland and has high morphological complexity. However, the origin and...
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Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism
Oral potentially malignant disorders (OPMDs) are precursors of oral squamous cell carcinoma (OSCC). Deregulated cellular energy metabolism is a...
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Divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice
The anterior disc displacement (ADD) leads to temporomandibular joint osteoarthritis (TMJOA) and mandibular growth retardation in adolescents. To...
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Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation
The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient...
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The interaction between the nervous system and the stomatognathic system: from development to diseases
The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the...
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LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling
Orthodontically induced tooth root resorption (OIRR) is a serious complication during orthodontic treatment. Stimulating cementum repair is the...
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Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects. Recent...
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Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing
Carious lesions are bacteria-caused destructions of the mineralised dental tissues, marked by the simultaneous activation of immune responses and...
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Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling
Carcinoma-associated fibroblasts (CAFs) are the main cellular components of the tumor microenvironment and promote cancer progression by modifying...
