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Association between inflammatory factors and melanoma: a bidirectional Mendelian randomization study
PurposeThis study performed a bidirectional Mendelian randomization (MR) analysis to elucidate the causal relationships of C-reactive protein and 41...
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Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
BackgroundStreptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust...
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The role of blood related inflammatory factors on age-related macular degeneration (AMD)
BackgroundAge-related macular degeneration (AMD) is a significant retinal disease that leads to irreversible low vision, particularly in develo**...
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Plasmodium falciparum neonatal malaria with atypical presentation: a case series from southwestern Ethiopia
BackgroundNeonatal malaria is defined as the detection of asexual stages of Plasmodium species in the cord blood within the first 28 days of life....
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Insufficient duration of insecticidal efficacy of Yahe® insecticide-treated nets in Papua New Guinea
BackgroundInsecticide-treated nets (ITNs) are the backbone of anti-malarial vector control in Papua New Guinea (PNG). Over recent years the quality...
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Severe malaria intervention status in Nigeria: workshop meeting report
Nigeria accounts for 39% of global malaria deaths in children under 5 years of age and the effective management of severe malaria is a health...
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Defining the next generation of severe malaria treatment: a target product profile
BackgroundSevere malaria is a life-threatening infection, particularly affecting children under the age of 5 years in Africa. Current treatment with...
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Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines
Vaccination has proven to be a valuable tool to combat SARS-CoV-2. However, reports of rare adverse reactions such as thrombosis/thrombocytopenia...
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Bioequivalence of a new coated 15 mg primaquine formulation for malaria elimination
BackgroundWith only one 15 mg primaquine tablet registered by a stringent regulatory authority and marketed, more quality-assured primaquine is...
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Physical and insecticidal durability of Interceptor®, Interceptor® G2, and PermaNet® 3.0 insecticide-treated nets in Burkina Faso: results of durability monitoring in three sites from 2019 to 2022
BackgroundNational Malaria Programmes (NMPs) monitor the durability of insecticide-treated nets (ITNs) to inform procurement and replacement...
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein
A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV)...
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Tracing household transmission of SARS-CoV-2 in New Zealand using genomics
By early 2022, the highly transmissible Omicron variant of SARS-CoV-2 had spread across most of the world. For the first time since the pandemic...
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75 years’ journey of malaria publications in English: what and where?
Malaria has inflicted serious morbidity and mortality across the globe. The major brunt of the disease has been on African, South-East Asian and...
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Prevalence of congenital anomalies and prenatal diagnosis by birth institution (public vs. non-public): indicators of inequality in access to elective termination of pregnancy for fetal anomalies
Congenital anomalies (CA) encompass all morphological or functional alterations originating prenatally and present at birth. The prenatal diagnosis...
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The effect of mailed outreach on FIT completion among patients aged 45–50 in a safety net healthcare system
PurposeColorectal cancer screening is recommended starting at age 45, but there has been little research on strategies to promote screening in...
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Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection
Influenza A virus (IAV) causes significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. The antigenic...
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Examining the paradox: increased malaria risk in children under 5 in female-headed households in Nigeria
BackgroundNigeria is facing a severe malaria crisis, accounting for a significant proportion of global cases and deaths of malaria. This study aimed...
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Neoantigen-augmented iPSC cancer vaccine combined with radiotherapy promotes antitumor immunity in poorly immunogenic cancers
Although irradiated induced-pluripotent stem cells (iPSCs) as a prophylactic cancer vaccine elicit an antitumor immune response, the therapeutic...
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Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
Current Influenza virus vaccines primarily induce antibody responses against variable epitopes in hemagglutinin (HA), necessitating frequent updates....
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Health workers’ adherence to malaria case management protocols in Northern Sudan: a qualitative study
BackgroundNonadherence to national standards for malaria diagnosis and treatment has been reported in Sudan. In this study, qualitative research...
