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Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta
As a risk factor for Alzheimer’s disease (AD), studies have demonstrated that long-term high-fat diet (HFD) could accelerate the deposition of...
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Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex—A Possible Link to Microcircuitry Specialization
Perineuronal nets (PNNs) are a type of extracellular matrix (ECM) that play a significant role in synaptic activity and plasticity of interneurons in...
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From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer’s Disease
Alzheimer’s disease is a progressive neurodegenerative disorder that affects memory and cognitive abilities, affecting millions of people around the...
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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
BackgroundLeveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive...
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Developmental change of brain volume in Rett syndrome in Taiwan
ObjectiveRett syndrome (RTT) is characterized by neurological regression. This pioneering study investigated the effect of age on brain volume...
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Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and has a great socio-economic impact. Modified oxidative lipid...
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Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
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Heat-related illness and dementia: a study integrating epidemiological and experimental evidence
BackgroundHeat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We...
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Omega-3 Attenuates Disrupted Neurotransmission and Partially Protects Metabolic Dysfunction Caused by Obesity in Wistar Rats
Omega-3 (n3) is a polyunsaturated fatty acid well known for its anti-inflammatory and neuroprotective properties. Obesity is linked to chronic...
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Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
BackgroundEnlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer’s disease (AD) and inversely correlated with cognitive...
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Static and temporal dynamic alterations of regional homogeneity in chronic insomnia: a resting-state fMRI study
To explore brain function alterations in chronic insomnia (CI). 65 CI patients and 48 healthy controls were included to analyze abnormal alterations...
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Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling
BackgroundType 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are mutual risk factors, with both conditions inducing cognitive...
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Pioneers of cortical cytoarchitectonics: the forgotten contribution of Herbert Major
The study of cortical cytoarchitectonics and the histology of the human cerebral cortex was pursued by many investigators in the second half of the...
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The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway
Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are...
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A Comprehensive Overview of NF1 Mutations in Iranian Patients
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in the NF1 gene. This disorder shows nearly complete penetrance and high...
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Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology
Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite...
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BI1 Activates Autophagy and Mediates TDP43 to Regulate ALS Pathogenesis
Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disease in adults. Currently, there are no known drugs or clinical approaches...
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A Method to Extract Task-Related EEG Feature Based on Lightweight Convolutional Neural Network
Unlocking task-related EEG spectra is crucial for neuroscience. Traditional convolutional neural networks (CNNs) effectively extract these features...
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The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been...
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The influence of travel time on perceived traveled distance varies by spatiotemporal scale
The influence of travel time on perceived traveled distance has often been studied, but the results are inconsistent regarding the relationship...
