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A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m 6 A) modifications. A better understanding of the...
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An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score
Heart failure with preserved ejection fraction (HFpEF) is under-recognized in clinical practice. Although a previously developed risk score, termed H 2 ...
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Hippocampal network activity forecasts epileptic seizures
Seizures in people with epilepsy were long thought to occur at random, but recent methods for seizure forecasting enable estimation of the likelihood...
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Drug repurposing: a retrospective revolution in breast cancer medicine
Breast cancer is a complex disease involving numerous pathways, making effective treatment quite challenging. Among the current scenario, drug...
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Understanding the impact of COVID-19 on antibiotic use in Canadian primary care: a matched-cohort study using EMR data
BackgroundInappropriate or overuse of antibiotic prescribing in primary care highlights an opportunity for antimicrobial stewardship (AMS) programs...
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Pegylated recombinant human granulocyte colony-stimulating factor for primary prophylaxis of neutropenia in patients with cervical cancer receiving concurrent chemoradiotherapy: a prospective study
BackgroundThis study aimed to investigate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF)...
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Highly Sensitive and Selective Fluorescence and Smartphone-Based Sensor for Detection of Rutin Using Boron Nitrogen Co-doped Graphene Quantum Dots
This research explores the fluorescence properties and photostability of boron nitrogen co-doped graphene quantum dots (BN-GQDs), evaluating their...
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An 18-gene signature of recurrence-associated endothelial cells predicts tumor progression and castration resistance in prostate cancer
BackgroundThe prognostic and therapeutic implications of endothelial cells (ECs) heterogeneity in prostate cancer (PCa) are poorly understood.
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Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers
BackgroundFusobacterium nucleatum inhabits the oral cavity and affects the progression of gastrointestinal cancer. Our prior findings link F....
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Prevalence of diabetes among Indigenous women in Guatemala: a retrospective chart review
ObjectiveThe objective of this study is to investigate the prevalence of diabetes in a clinical population of primarily Indigenous women in Guatemala.
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A Review on Small Molecule Based Fluorescence Chemosensors for Bioimaging Applications
This review provides a thorough examination of small molecule-based fluorescence chemosensors tailored for bioimaging applications, showcasing their...
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Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
PurposeDual-Interventions targeting glucose and oxidative metabolism are receiving increasing attention in cancer therapy. Sorafenib (S) and...
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Staphylococcus aureus screening and preoperative decolonisation with Mupirocin and Chlorhexidine to reduce the risk of surgical site infections in orthopaedic surgery: a pre-post study
BackgroundNasal carriage of Staphylococcus aureus is a risk factor for surgical site infections (SSI) in orthopaedic surgery. The efficacy of...
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ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway
BackgroundEmerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Understanding the...
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Eyecare-cloud: an innovative electronic medical record cloud platform for pediatric research and clinical care
Background and objectivesClinical data are essential for develo** cloud platforms for intelligent diagnosis and treatment decision of diseases....
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From bench to bedside: the application of cannabidiol in glioma
Glioma is the most common malignant tumor in central nervous system, with significant health burdens to patients. Due to the intrinsic...
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N6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
BackgroundThe potential involvement of circular RNAs (circRNAs) and N 6 -methyladenosine (m 6 A) modification in the progression of Wilms tumor (WT) has...
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Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use...
