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Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis
Triple-negative breast cancer (TNBC) is incurable and prone to widespread metastasis. Therefore, identification of key targets for TNBC progression...
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Antibody targeting of anaerobic bacteria warms cold tumors and improves the abscopal effect of radiotherapy
BackgroundThe combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant...
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Endoplasmic reticulum stress promotes hepatocellular carcinoma by modulating immunity: a study based on artificial neural networks and single-cell sequencing
IntroductionHepatocellular carcinoma (HCC) is characterized by the complex pathogenesis, limited therapeutic methods, and poor prognosis. Endoplasmic...
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Finite element simulation of treatment with locking plate for distal fibula fractures
An improved Finite Element Model(FEM) is applied to compare the biomechanical stability of plates with three different options in the treatment of...
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Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies
Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral infections. Numerous studies...
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DBScope as a versatile computational toolbox for the visualization and analysis of sensing data from deep brain stimulation
Different neurostimulators for deep brain stimulation (DBS) come already with the ability to chronically sense local field potentials during...
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Fluorescence Studies on the Binding Affinity and Determination of Vitamin B12 in the Presence of Fibrinogen
The binding properties between vitamin B12 (vitB12, cyanocobalamin) and fibrinogen (Fib) were investigated by UV-vis absorption and...
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Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial
Consumer-grade wearable technology has the potential to support clinical research and patient management. Here, we report results from the RATE-AF...
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A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we address the possibility that the...
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Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental tools that allow for the...
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The immunology of systemic lupus erythematosus
Understanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches...
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Deep source transfer learning for the estimation of internal brain dynamics using scalp EEG
Electroencephalography (EEG) provides high temporal resolution neural data for brain-computer interfacing via noninvasive electrophysiological...
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Efficacy of chemotherapy plus immune checkpoint inhibitors in patients with non-small cell lung cancer who have rare oncogenic driver mutations: a retrospective analysis
BackgroundTargeted therapy is now the standard of care in driver–oncogene-positive non-small cell lung cancer (NSCLC). Its initial clinical effects...
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Ile-Pro-Pro attenuates sympathetic activity and hypertension
Isoleucine-proline-proline (Ile-Pro-Pro, IPP) is a natural food source tripeptide that inhibits angiotensin-converting enzyme (ACE) activity. The aim...
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The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion in annual healthcare expenditures only in the United...
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Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects
Immunotherapies for cancer, specifically immune checkpoint inhibition (ICI), have shown potential in reactivating the body’s immune response against...
