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Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis
BackgroundLipid-lowering drugs are widely used among the elderly, with some studies suggesting links to muscle-related symptoms. However, the...
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hsp70 PCR–RFLP as an alternative tool to identify Sauroleishmania species
Sauroleishmania spp . comprises one of the four Leishmania subgenera, which has been historically considered a non-pathogenic protozoan of reptiles....
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Abbott realtime MTB assay for detecting Mycobacterium tuberculosis complex in respiratory specimens: a cost-benefit analysis
PurposeMolecular screening for Mycobacterium tuberculosis (MTB) can lead to rapid empirical treatment inception and reduce hospitalization time and...
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Genomic insights into Leminorella grimontii and its chromosomal class A GRI β-lactamase
Leminorella grimontii strain LG-KP-E1-2-T0 was isolated from Zophobas morio larvae. It showed a susceptibility phenotype compatible with the...
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Population structure and haplotype network analyses of Hyalomma anatolicum based on the large subunit ribosomal RNA (16S rRNA) gene
Hyalomma anatolicum , an Anatolian hard tick is a well-recognized vector involved in the transmission of various pathogens to animals and humans. The...
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Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: toward a new paradigm
PurposeData on short courses of antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients are limited. The aim of the...
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Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression
BackgroundAging represents a significant risk factor for the occurrence of cerebral small vessel disease, associated with white matter (WM) lesions,...
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Comparative Analysis of Complete Mitochondrial Genomes of Five Chromodorididae Species (Nudibranchia:Doridina)
Mitochondrial genome is an important molecular marker for exploring the phylogenetic relationships of species and revealing molecular evolution. In...
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Evaluation of Seroprevalence and Risk Factors of Heartworm Infection for Dogs in Rio de Janeiro with Access to Veterinary Care
Heartworm infection is a chronic disease with clinical signs and effects ranging from an asymptomatic condition to severe disease and death. The...
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Metabolomic Approach to Identify the Potential Metabolites from Alpinia malaccensis for Treating SARS-CoV-2 Infection
The advent of the new coronavirus, leading to the SARS-CoV-2 pandemic, has presented a substantial worldwide health hazard since its inception in the...
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The cuproptosis-related signature predicts the prognosis and immune microenvironments of primary diffuse gliomas: a comprehensive analysis
BackgroundEvidence has revealed a connection between cuproptosis and the inhibition of tumor angiogenesis. While the efficacy of a model based on...
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Quantifying functional redundancy in polysaccharide-degrading prokaryotic communities
BackgroundFunctional redundancy (FR) is widely present, but there is no consensus on its formation process and influencing factors. Taxonomically...
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Oral HPV infection clearance and acquisition after nonavalent vaccination in men who have sex with men and transgender women: a prospective analysis
Oral HPV infection is the main risk factor for the development of oropharyngeal carcinoma. Men who have sex with men (MSM), especially if living with...
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A novel variant in GAS2 is associated with autosomal dominant nonsyndromic hearing impairment in a Chinese family
Knockout of GAS2 (growth arrest-specific protein 2), causes disorganization and destabilization of microtubule bundles in supporting cells of the...
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A modified mycobacterial growth inhibition assay for the functional assessment of vaccine-mediated immunity
The Mycobacterial growth inhibition assay (MGIA) is an ex-vivo assay used to measure the overall functional immune response elicited by infection or...
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High Expression of miR-218-5p in the Peripheral Blood Stream and Tumor Tissues of Pediatric Patients with Sarcomas
Sarcomas are malignant tumors that may metastasize and the course of the disease is highly aggressive in children and young adults. Because of the...
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A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,...
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Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye
Molecular diagnosis of inborn errors of immunity (IEI) plays a critical role in determining patients’ long-term prognosis, treatment options, and...
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Serotype distribution, antibiotic resistance, multilocus sequence ty**, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021
Streptococcus pneumoniae infection is a major public health concern with high morbidity and mortality rates. This study aimed to evaluate the...
